Brief reportProfound alkalemia during treatment of tricyclic antidepressant overdose: A potential Hazard of combined hyperventilation and intravenous bicarbonate
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Cited by (31)
Reversal of severe tricyclic antidepressant-induced cardiotoxicity with intravenous hypertonic saline solution
2003, Annals of Emergency MedicineCitation Excerpt :Serum alkalinization by means of intravenous bolus therapy with sodium bicarbonate, as well as hyperventilation, resulted in pH values in the target range of 7.5 to 7.55. Further therapy with sodium bicarbonate was avoided in our patient because of concerns over potentially harmful effects of excessive alkalization.5 Because of continued deterioration in the form of worsening hypotension, ectopy, and QRS interval widening despite maximal standard therapy, hypertonic saline solution was administered to optimize extracellular sodium concentrations without the additional pH increase that would accompany sodium bicarbonate.
Tox-ACLS: Toxicologic-oriented advanced cardiac life support
2001, Annals of Emergency MedicineAcute lung failure induced by tricyclic antidepressants
1997, Toxicology and Applied PharmacologyCardiovascular complications of seizures during cyclic antidepressant poisoning
1997, Reanimation UrgencesInterfacility Critical Care Transport of an Elderly Patient With Confirmed Tricyclic Antidepressant Toxicity and Hemodynamic Collapse
2019, Air Medical JournalCitation Excerpt :Current recommendations related to respiratory therapies include compliance with ARDSnet lung protective guidelines such as maintenance of low tidal volumes, physiologic respiratory rates, and the application of positive end-expiratory pressure to avoid lung derecruitment and atelectasis.1,2 A combined strategy of induced respiratory alkalosis and serum alkalization has been linked to profound metabolic alkalosis and increased mortality.7 Case studies and review articles highlight other potential therapies.