Elsevier

American Heart Journal

Volume 131, Issue 6, June 1996, Pages 1214-1216
American Heart Journal

Brief communication
Ventricular fibrillation after intravenous amiodarone in Wolff-Parkinson-White syndrome with atrial fibrillation

https://doi.org/10.1016/S0002-8703(96)90098-8Get rights and content

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  • Efficacy of amiodarone in a case with pre-excited atrial fibrillation with a precarious conduction property of the accessory pathway

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    It is known that the effects of amiodarone in the acute phase enhance the inhibition of inward sodium and calcium currents, whereas voltage- and ligand-gated potassium channel currents are decreased with oral administration in the chronic phase.5 Furthermore, intravenous amiodarone administration may have a more prevalent effect on AV node conduction than on AcP conduction.3 Intravenous amiodarone administration has calcium channel-blocking activity, which has a rate-dependent effect on AV node conduction (the greater the effect, the more rapid the rate, such as AF conduction).6

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