Elsevier

The Lancet

Volume 333, Issue 8641, 8 April 1989, Pages 768-771
The Lancet

Before our Time
THE ORIGINS OF INTRAVENOUS FLUID THERAPY

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  • We van Heyningen et al.

    Cholera: the American scientific experience 1947-1980

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  • GG. Nahas

    Marihuana—deceptive weed

    (1973)
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    Thomas Latta used the pandemic of cholera in the 1880s to demonstrate that fluid replacement was the necessary and sufficient treatment, concluding that “one third of is moribund patients were restored to the world”.5,8 Intravenous infusion therapy was still not universally accepted in the 1800s, perhaps due to well-meaning but ill-fated infusions of non-sterile water, cow's milk, albumin, and various salt concentrations.9 One can imagine a significant mortality rate from such interventions related to infection, air embolus, hemolysis, hyponatremia, and anaphylaxis.

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