Succinylcholine: Adverse effects and alternatives in emergency medicine
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Cited by (54)
Neuromuscular blocking agents and skeletal muscle relaxants
2022, Side Effects of Drugs AnnualCitation Excerpt :These agents are categorized as either depolarizing or nondepolarizing neuromuscular blockers and use of these medications results in transient paralysis. Succinylcholine, the only available depolarizing agent, has been associated with hyperkalemia, bradycardia, malignant hyperthermia, muscle fasciculations, myalgias, rhabdomyolysis, and increased intraocular and intracranial pressure (Stollings et al., 2014 [R]; Orebaugh, 1999 [R]). The risk of adverse effects is increased in patients with plasma cholinesterase (butyrylcholinesterase) deficiency due its role in the metabolism of succinylcholine (Fig. 1) (Brazzolotto et al., 2021 [A]; Millet et al., 2021 [c]; Sasidharan & Dhillon, 2021 [A]).
Low-Dose of Rocuronium During Thyroid Surgery: Effects on Intraoperative Nerve-Monitoring and Intubation
2021, Journal of Surgical ResearchApproach to Acute Weakness
2021, Emergency Medicine Clinics of North AmericaCitation Excerpt :If rapid sequence intubation is deemed necessary, consider avoiding depolarizing neuromuscular blocking agents such as succinylcholine. These agents carry the risk of potentially fatal hyperkalemia in those with neurologic disease by amplifying the succinylcholine-related cellular potassium release.4,5 For most relevant conditions, this response occurs in those with symptoms or illness for 3 or more days.
Neuromuscular blocking agents and skeletal muscle relaxants
2021, Side Effects of Drugs AnnualContraindications to succinylcholine in the intensive care unit. A prevalence study
2015, Medicina IntensivaA comparison between succinylcholine and rocuronium on the recovery profile of the laryngeal muscles during intraoperative neuromonitoring of the recurrent laryngeal nerve: A prospective porcine model
2013, Kaohsiung Journal of Medical SciencesCitation Excerpt :The second benefit is pharmacological safety. However, diverse adverse effects ranging from minor (e.g., muscle pain, dysrhythmia) to lethal (e.g., malignant hyperthermia, hyperkalemia) limit its clinical application [13,14]. Succinylcholine also has a short duration; however, it is responsible for most incidents of NMBA-related anaphylaxis [15].