Chest
Clinical InvestigationsINFECTIONSPlasma d-Dimer Levels Correlate With Outcomes in Patients With Community-Acquired Pneumonia
Section snippets
Patients
From January 1, 2000, to October 31, 2002, in the Hospital Lluis Alcanyis (Xativa, Spain), blood samples were prospectively obtained from patients who were > 16 years of age and had received a diagnosis of CAP. CAP was defined as an opacity that was consistent with the presence of acute pneumonia on the chest radiograph (CXR) and was associated with respiratory symptoms, infectious syndrome, and lack of an alternative diagnosis. Blood was obtained from all patients in the emergency service from
Results
During the study period, 405 patients were initially analyzed. Of these, 20 patients were excluded from the study because they had a high probability of PE. In addition, 18 patients with CAP criteria were excluded from the study due to neutropenia (10 patients), hematologic cancer (6 patients), and previous hospital admission (2 patients). Finally, 65 patients were excluded from the study because d-dimer measurements had been performed 24 to 48 h after starting antibiotic treatment. Thus, the
Discussion
As far as we know, no relationship between d-dimer status and CAP has been reported. This prospective study found that d-dimer status was often positive in patients with newly diagnosed CAP. Moreover, this study has demonstrated that in-hospital mortality was significantly greater among patients with high d-dimer levels. d-Dimer levels correlated with well-established scoring systems for outcome prediction purposes such as APACHE II score and PSI. However, the relationship between d-dimer level
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