Chest
EditorialsEarly Goal-Directed Therapy in Severe Sepsis and Septic Shock: Converting Science to Reality
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Cited by (42)
Comparison of the predictive ability of lactate and central venous blood gas in pediatric venoarterial mode extracorporeal membrane oxygenation outcome
2022, Pediatrics and NeonatologyCitation Excerpt :Since then, many studies have discussed the relationship between lactate and sepsis.31–33 Lactate-guided resuscitation is highly valuable for sepsis resuscitation, rather than hemodynamic-guided resuscitation, as it is a parameter for microcirculation.34–36 Serial lactate monitoring is generally accepted in the management of sepsis and cardiac surgery for congenital heart disease.37–39
Emergency department sepsis huddles: Achieving excellence for sepsis benchmarks in New York State
2020, American Journal of Emergency MedicineCitation Excerpt :Prior to 2001, a standard for the management of sepsis in the ED did not exist [1]. With the publication of Dr. Emmanuel Rivers' paper on Early Goal Directed Therapy [2], it appeared that this early management led to a significant decrease in mortality. Dr. Rivers formally established the need for emergent resuscitation in the setting of severe sepsis.
Which one is a better predictor of ICU mortality in septic patients? Comparison between serial serum lactate concentrations and its removal rate
2018, Journal of Critical CareCitation Excerpt :Septic shock is one of the leading causes of mortality in intensive care units worldwide. There are some concerns regarding the international recommendation of early goal-directed therapy (EGDT) [1,2], based on optimization of central venous O2 saturation (ScvO2), mean arterial pressure, central venous pressure and urine output in terms of decreasing mortality [3-5]. However, it was determined that EGDT was not superior to standard sepsis management [3-5].
Cooling the Fire. Resuscitated Sudden Death
2012, Cardiology ClinicsCitation Excerpt :Scvo2 must be measured from a central venous catheter placed in the subclavian or internal jugular vein. The recommended target of Scvo2 is greater than 70%.4,12 Regarding lactate, there is no significant difference between arterial and venous samples; values greater than 2 mmol/L are considered abnormal.
Evaluation of a modified early goal-directed therapy protocol
2010, American Journal of Emergency MedicineCitation Excerpt :Other institutions have also been able to show a reduction in mortality after implementing standard protocols for the ED treatment of the septic patient [6-10]. Despite these promising results, EGDT has not been widely implemented [11-13]. In May 2005, we implemented a modified EGDT protocol at our large, suburban community teaching hospital.
Dr. Rivers has done consultant work for Biosite, Inc., Chiron, the Lilly Corporation, and Edwards Lifesciences over the last year. As a consultant, he helped advise the company in developing, but holds no patent rights to, catheters used for early, goal-directed therapy.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).