Abstract
Clinical question:
In patients with respiratory tract infection, is measurement of procalcitonin to guide antibiotic prescriptions associated with reduced antibiotic exposure without increases in all-cause mortality or treatment failure?
Bottom line:
The measurement of procalcitonin to guide initiation and duration of antibiotic treatment in patients with respiratory tract infections of varying severity is associated with lower antibiotic exposure without increasing all-cause mortality or treatment failure.
MeSH terms
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Adult
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Aged
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Algorithms*
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Anti-Bacterial Agents / administration & dosage*
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Biomarkers / blood
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Calcitonin / blood*
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Calcitonin Gene-Related Peptide
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Drug Administration Schedule
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Evidence-Based Medicine
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Female
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Humans
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Male
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Middle Aged
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Protein Precursors / blood*
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Randomized Controlled Trials as Topic
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Respiratory Tract Infections / blood*
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Respiratory Tract Infections / drug therapy*
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Respiratory Tract Infections / mortality
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Severity of Illness Index
Substances
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Anti-Bacterial Agents
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Biomarkers
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CALCA protein, human
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Protein Precursors
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Calcitonin
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Calcitonin Gene-Related Peptide