Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis

C Mohan, C Putterman - Nature Reviews Nephrology, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …

Neuropsychiatric lupus: new mechanistic insights and future treatment directions

N Schwartz, AD Stock, C Putterman - Nature Reviews Rheumatology, 2019 - nature.com
Patients with systemic lupus erythematosus (SLE) frequently show symptoms of central
nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS …

The impact of COVID‐19 on the mental health and wellbeing of caregivers of autistic children and youth: A scoping review

…, T Hedley, P Johnston, C Putterman… - Autism …, 2021 - Wiley Online Library
Caregivers and families of autistic people have experienced stress and increase in
demands due to the COVID‐19 pandemic that may have long‐term negative consequences …

The immune cell landscape in kidneys of patients with lupus nephritis

…, EA McInnis, JP Buyon, MA Petri, C Putterman… - Nature …, 2019 - nature.com
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is
ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed …

The spectrum of septic encephalopathy: definitions, etiologies, and mortalities

LA Eidelman, D Putterman, C Putterman, CL Sprung - Jama, 1996 - jamanetwork.com
Objective.—To determine whether the severity of septic encephalopathy is correlated with
gram-negative bacteremia and mortality and whether there exists a single or combination of …

[HTML][HTML] Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays

…, M Mackay, C Aranow, C Putterman… - The Journal of …, 2005 - Am Soc Clin Investig
Nephrophilic autoantibodies dominate the seroprofile in lupus, but their fine specificities
remain ill defined. We constructed a multiplexed proteome microarray bearing about 30 …

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

…, J James, J Buyon, T Tuschl, C Putterman - Nature …, 2019 - nature.com
The molecular and cellular processes that lead to renal damage and to the heterogeneity of
lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing …

[HTML][HTML] Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study

…, BH Rovin, JS Michaelson, C Putterman - Arthritis research & …, 2009 - Springer
Introduction TNF-like weak inducer of apoptosis (TWEAK) has been implicated as a
mediator of chronic inflammatory processes via prolonged activation of the NF-κB pathway …

[HTML][HTML] Metabolic disturbances associated with systemic lupus erythematosus

…, J Weiel, Q Li, I Blanco, C Ahn, N Olsen, C Putterman… - PloS one, 2012 - journals.plos.org
The metabolic disturbances that underlie systemic lupus erythematosus are currently
unknown. A metabolomic study was executed, comparing the sera of 20 SLE patients …

[HTML][HTML] PD-1hiCXCR5–T peripheral helper cells promote B cell responses in lupus via MAF and IL-21

…, SLE Network, M Petri, JP Buyon, C Putterman… - JCI insight, 2019 - ncbi.nlm.nih.gov
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathologic
T cell–B cell interactions and autoantibody production. Defining the T cell populations that …