Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay
Objectives: This paper sought to evaluate whether high sensitivity troponin (hs-cTnT) can
immediately exclude acute myocardial infarction (AMI) at a novel 'rule out'cut-off …
immediately exclude acute myocardial infarction (AMI) at a novel 'rule out'cut-off …
Factors predicting anaphylaxis to peanuts and tree nuts in patients referred to a specialist center
CW Summers, RS Pumphrey, CN Woods… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Although acute allergic reactions after ingestion of peanuts and tree nuts
are common, fatalities are rare. Other than patients with coexisting asthma, it is currently not …
are common, fatalities are rare. Other than patients with coexisting asthma, it is currently not …
Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate
WB Dunn, DI Broadhurst, SM Deepak, MH Buch… - Metabolomics, 2007 - Springer
There is intense interest in the identification of novel biomarkers which improve the
diagnosis of heart failure. Serum samples from 52 patients with systolic heart failure (EF< …
diagnosis of heart failure. Serum samples from 52 patients with systolic heart failure (EF< …
The value of symptoms and signs in the emergent diagnosis of acute coronary syndromes
OBJECTIVE: Patient history and physical examination are widely accepted as cornerstones
of diagnosis in modern medicine. We aimed to assess the value of individual historical and …
of diagnosis in modern medicine. We aimed to assess the value of individual historical and …
Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid: single biomarker re-derivation and external validation in three cohorts
Background The original Manchester Acute Coronary Syndromes model (MACS)'rules
in'and 'rules out'acute coronary syndromes (ACS) using high sensitivity cardiac troponin T …
in'and 'rules out'acute coronary syndromes (ACS) using high sensitivity cardiac troponin T …
[HTML][HTML] Examining the efficacy of six published time-lapse imaging embryo selection algorithms to predict implantation to demonstrate the need for the development of …
A Barrie, R Homburg, G McDowell, J Brown… - Fertility and sterility, 2017 - Elsevier
Objective To study the efficacy of six embryo-selection algorithms (ESAs) when applied to a
large, exclusive set of known implantation embryos. Design Retrospective, observational …
large, exclusive set of known implantation embryos. Design Retrospective, observational …
The endopeptidase inhibitor, candoxatril, and its therapeutic potential in the treatment of chronic cardiac failure in man
G McDowell, DP Nicholls - Expert opinion on investigational drugs, 1999 - Taylor & Francis
Candoxatril (UK-79300) is the orally-active prodrug of candoxatrilat (UK-73967), the active
enantiomer of (±) candoxatrilat (UK-69578), a potent neutral endopeptidase (NEP) inhibitor …
enantiomer of (±) candoxatrilat (UK-69578), a potent neutral endopeptidase (NEP) inhibitor …
The Manchester Acute Coronary Syndromes (MACS) decision rule for suspected cardiac chest pain: derivation and external validation
Objective We aimed to derive and validate a clinical decision rule (CDR) for suspected
cardiac chest pain in the emergency department (ED). Incorporating information available at …
cardiac chest pain in the emergency department (ED). Incorporating information available at …
Preliminary investigation of the prevalence and implantation potential of abnormal embryonic phenotypes assessed using time-lapse imaging
A Barrie, R Homburg, G McDowell, J Brown… - Reproductive …, 2017 - Elsevier
This retrospective, single site observational study aimed to delineate five abnormal
embryonic developmental phenotypes, assessing their prevalence, development potential …
embryonic developmental phenotypes, assessing their prevalence, development potential …
Do risk factors for chronic coronary heart disease help diagnose acute myocardial infarction in the Emergency Department?
BACKGROUND: Hypertension, hyperlipidaemia, diabetes mellitus, tobacco smoking and a
family history of premature coronary artery disease are known to be risk factors for the …
family history of premature coronary artery disease are known to be risk factors for the …