Ulcerative colitis and Crohn's disease are the principal forms of inflammatory bowel disease.
Both represent chronic inflammation of the gastrointestinal tract, which displays …

The British Society of Gastroenterology (BSG) and the Association of Coloproctology for
Great Britain and Ireland (ACPGBI) commissioned this update of the 2002 guidance. The …

Genome-wide association studies have recently identified ten common genetic variants
associated with colorectal cancer susceptibility, several suggesting the involvement of …

HEREDITARY nonpolyposis colorectal cancer (HNPCC) is one of man's commonest
hereditary diseases1. Several studies have implicated a defect in DNA mismatch repair in …

WE have hypothesized that end-to-end chromosome fusions observed in some tumours
could play a part in genetic instability associated with tumorigenesis and that fusion may …

Background Observational studies report reduced colorectal cancer in regular aspirin
consumers. Randomised controlled trials have shown reduced risk of adenomas but none …

Using a multistage genetic association approach comprising 7,480 affected individuals and
7,779 controls, we identified markers in chromosomal region 8q24 associated with …

Estimating individual genome-wide autozygosity is important both in the identification of
recessive disease variants via homozygosity mapping and in the investigation of the effects …

To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide
association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal …

In a genome-wide association study to identify loci associated with colorectal cancer (CRC)
risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 …