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Tricyclic antidepressant overdose: a review
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  • Published on:
    Flumazenil is contraindicated in mixed tricyclic and benzodiazepine overdose
    • Richard M Lynch, Specialist Registrar A&E
    • Other Contributors:
      • Richard M Lynch

    Dear Editor

    I read with interest Kerr et al’s highly informative article, Tricyclic antidepressant overdose: a review.[1] However, I would like to highlight an important point which the authors have not mentioned. In cases of mixed overdose, of tricyclic antidepressants and benzodiazepines, flumazenil (Anexate) is contraindicated. It has produced convulsions and ventricular arrhythmias in the presence of tricyclics....

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    Conflict of Interest:
    None declared.
  • Published on:
    Tricyclic antidepressant overdose
    • Cathy Kelly, Consultant Physician
    • Other Contributors:
      • Catherine Kelly

    Dear Editor,

    Kerr et al[1] point out in their review that despite the introduction of newer antidepressant agents in recent years, a large number of prescriptions for tricyclic antidepressants are still issued. Data from our unit suggests that overdose with selective serotonin re-uptake inhibitors (SSRIs) has now become more common than with tricyclic antidepressants. Despite this, there were 4981 accesses to i...

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    Conflict of Interest:
    None declared.