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Physostigmine as treatment for severe CNS anticholinergic toxicity
  1. R Teoh,
  2. A-V Page,
  3. R Hardern
  1. Acute Medical Assessment Area, The General Infirmary, Leeds LS1 3EX, UK
  1. Correspondence to: Dr Hardern (rhardern{at}

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Editor,—We report the successful use of physostigmine to treat central anticholinergic toxicity: a use described before but rarely seen.1 We treated a patient admitted after an overdose of amisulpride and procyclidine (not his own medication). He became extremely agitated and was treated with intravenous benzodiazepines (total quantity in 26 hours equivalent to 125 mg diazepam) but remained agitated. Because …

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