• best evidence topic reports
• opioids
• paracetamol
• naloxone
• gastric lavage

Best evidence topic reports (BETs) summarise the evidence pertaining to particular clinical questions. They are not systematic reviews, but rather contain the best (highest level) evidence that can be practically obtained by busy practising clinicians. The search strategies used to find the best evidence are reported in detail in order to allow clinicians to update searches whenever necessary. The BETs published below were first reported at the Critical Appraisal Journal Club at the Manchester Royal Infirmary.¹ Each BET has been constructed in the four stages that have been described elsewhere.² The BETs shown here together with those published previously and those currently under construction can be seen at http://www.bestbets.org.³ Six BETs are included in this issue of the journal.

• Oral or intravenous antidote for paracetamol overdose

• Vomiting in paracetamol overdose

• Intravenous or intramuscular/subcutaneous naloxone in opioid overdose

• Intravenous bolus or infusion of naloxone in opioid overdose

• Discharge of patients who have taken an overdose of opioids

• Gastric lavage in iron overdose