Objectives: To compare the costs of two strategies for acute management of mild head injury: inhospital observation compared with acute computed tomography (CT) and home care.
Methods: Studies comparing costs for the two strategies that seem to have similar outcomes for patients were systematically reviewed. A decision tree analysis to compare the costs was also constructed, based on Swedish national costs and the risks found in a recent review on mild head injury complications.
Results: No studies were found that directly measured and compared risks, benefits, and costs of the two strategies. In the four studies retrieved, involving 4126 patients, the costs for hospital observation were factual, but a model was used to evaluate costs for the CT strategy. On average, costs were one third lower with CT. Also, the decision tree analysis demonstrated that the CT strategy was one third less expensive than inhospital observation. A sensitivity analysis showed this to be valid for nearly all cases. If these calculations hold true, a change of strategy could result in annual savings of £280 000/million inhabitants.
Conclusion: The CT strategy seems to cost one third less than hospital observation.
- computed tomography
- head injury
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Mild head injury is one of the most common reasons for hospital admission after trauma. Annually, 17 000 patients (190/100 000 inhabitants) are admitted with mild head injuries in Sweden.1 Direct costs for the acute management of mild head injury in Sweden are estimated to be £7.6 million annually, £84 000/100 000 inhabitants.2 The indirect costs could not be reliably estimated, but seem to be considerably higher than the direct costs.
No uniform guidelines for the care of mild head injury are broadly accepted. Sweden and many other European countries have a longstanding tradition of managing mild head injury with inhospital observation.3–7 Some of the admitted patients receive a computed tomography (CT) scan in addition to inhospital care, around 20% in Sweden.4 The question has been raised concerning whether all patients with mild head injury instead can be triaged for admission with an early CT scan.8 Unnecessary admissions of patients with normal CT findings might thereby be avoided, and better care provided for patients with abnormal CT findings and at higher risk for deterioration with need for surgery or more intensive care. In our recent review of complications from mild head injury we estimated that even with the CT strategy at least 8% of the patients will require inhospital care because of abnormal CT findings or complications.9 It is also possible that an additional 10% might require admission because of organisational, medical, or social reasons despite normal CT findings.
The use of skull radiography to triage patients with mild head injury for admission or for CT has been discussed.1011 In Sweden, this method is not used routinely.4 Most evidence shows that skull radiography is less informative than CT and of limited value for the management of head injuries of a milder degree.1213 Furthermore, skull radiography carries a cost similar to CT, which even further lessens its value in a clinical setting where CT is available.14 For these reasons, CT seems to be the method of choice for admission triage in mild head injury and therefore the focus of this review.
Because of the high volume of patients with mild head injury, their management consumes considerable economic resources. Different management strategies for these patients have both medical and economic implications. The overall question is: Would a CT based strategy for patients with mild head injury be more effective or less costly than one based on inhospital observation? In general, there are few well designed studies of these patients.13 In fact, there is not a single randomised trial of strategies for their acute management. In a previous systematic review we found that no studies at all directly compared the medical risks and benefits of inhospital observation with those of CT and discharge.2 Both strategies appeared to be safe, with few reported severe complications and deaths. Other reviews have also pointed out the lack of properly designed, comparative trials and an absence of consistent definitions and measures of outcomes in head injury research.111315 This review considers the health economics of the two strategies. As there is presently not sufficient evidence to assign superiority in medical outcome to either one of the two strategies, the following analysis is performed as a cost minimisation study.
A search of the literature for cost comparisons regarding the two strategies was one way to find which was the least expensive, another was a decision tree analysis based on Swedish national costs and the probabilities found in our recent review.9
Mild head injury
The definition of mild head injury used in this report is short term loss of consciousness or amnesia, or both, as a result of skull trauma. Upon presenting in the emergency department, the patient should have regained a normal level of consciousness as measured by the Glasgow coma scale (GCS)16 and have normal neurological findings. Some definitions of mild head injury include GCS 13–15.17 The evidence shows that patients with GCS 13–14 have a significantly greater overall risk compared to patients with GCS 15.18 As the situation for patients with GCS 13–14 is more serious, the best group in which to initially try the home care strategy would be GCS 15. They also constitute the vast majority of patients with mild head injury.10 For these reasons, only GCS 15 was included in our analysis.
The frequency of abnormal findings from CT varies among studies depending on the definition used. Our review covers all abnormal CT findings that could be attributed to the head trauma. This includes intracranial bleeding (which dominates), skull fractures, and oedema.
Complication is defined broadly to include neurosurgical operation (which dominates), medical treatment of brain oedema, intracranial pressure monitoring and transfer to more intensive care.
The review process
Medline was searched from 1966 to May 2002. There are no generally accepted definitions for mild head injury, and indexing in the databases has changed over time. Hence, we conducted a broad search using multiple keywords in different combinations (see appendix for a full list of search terms). The Cochrane Library and OHE-HEED (a database of health economic studies) were also screened, as were reference lists of key studies and review articles. Studies in any language were accepted.
Costs according to literature
Relevant studies containing economic aspects were reviewed according to the principles proposed by Drummond et al.19 In our evaluation a study could at best fulfil all of Drummond’s 10 criteria, which are grouped under three headings: study design, data collection and analysis, and interpretation of results. As discounting does not fully apply to patients with short term outcomes, a maximum number of seven criteria are evaluated in this case.
Decision tree analysis
Decision tree analysis was used to compare the two strategies (Data 3.5 for healthcare, Treeage software, 1999).
The point at which a decision is made—that is, CT or inhospital observation—is marked with a box in figure 1. The two strategies end with circles, called “chance nodes”. Triangles are placed at the end of each outcome. Costs were calculated for all branches and totalled for each of the two strategies.
To estimate the costs in the decision tree analysis, we used Swedish national data on inhospital care for all patients with mild head injury (table 1).12491420 Average costs were used as the care of the great majority of patients admitted to the ward follow an uncomplicated course. Only direct costs in the acute phase were included in the analysis. All costs are presented in sterling (£) (£1 in 1998 = 13.17 SEK/1.66 US$). Rare events that did not affect the calculations were excluded in the figure to give a better overview (for example, readmission after normal CT with CT strategy and readmission after observation with observation strategy). The time span of the decision analysis is two days as the mean number of inpatient days in Sweden is 1.4 for patients with mild head injury.2 Furthermore, the lack of data on differences in medical outcome in the acute phase as well as long term, renders further comparison of the two strategies impossible.
The nature of clinical practice requires a mix of strategies. Therefore, the most probable scenario presupposes that 10% of patients would be admitted under the CT strategy despite normal CT findings (in addition to the 8% with abnormal CT findings). With the observation strategy 20% of patients would receive a CT scan despite being admitted, which was the mean in Sweden in 1998.
To test the robustness of the conclusions, probabilities, and costs were changed in a sensitivity analysis. Details concerning this analysis are found in figure 2.
Costs according to literature
Our literature search did not yield any economic studies of mild head injury where actual costs were measured and compared in patients managed under the two strategies. We found 12 studies containing economic aspects on these patients. Eight of the studies were excluded because they only discussed costs and did not report any findings,32122 or dealt only with the use of plain skull radiography.23–27
The four remaining studies used a model to estimate the costs of a CT strategy and compared them with real costs for patients admitted for inhospital observation (table 2).28–31 All studies were cost minimisation analyses based on data from 1985 to 1994. One was from Norway and three were from the United States.
All four studies fulfilled four of seven possible criteria for economic evaluations according to Drummond. In this regard, all had the same shortcomings: they used a model to estimate the cost of a CT strategy and no allowance for uncertainty was given (statistical significance, sensitivity analysis).
Included patients did not adhere strictly to the present definition of mild head injury as GCS 13–15 and 14–15 were accepted. In all four studies, a large majority of the patients had GCS 15, and they were therefore used. The inclusion of a few patients with GCS 13–14 most probably disfavours the CT strategy slightly in regards to costs. The frequency of abnormal findings on CT is higher in this group as compared with GCS 15, and more patients will subsequently require admission. Therefore, an economic advantage with CT and home care will be underestimated.
All four studies concluded that a CT based strategy for mild head injury would be less costly than one based on inhospital observation, and would decrease costs between 8% and 54% (table 2). On average, the costs would be one third lower. The absolute costs differ among the studies because of differences in what the calculations included. In the study reporting the least difference in costs between the two strategies, only 8%, the cost per bed day and the cost of a CT scan were about equal. In the three other studies the cost of a CT scan was considerably lower than a hospital bed day.
Decisions tree analysis
The decision analysis is presented in figure 1. The tree illustrates the probabilities for patients managed by the CT strategy compared with the observation strategy. Then, costs belonging to each outcome of all the branches are calculated and totalled for the two strategies. The cost of the CT strategy seems to be 36% lower than the cost for inhospital observation, or £300 compared with £470. This difference is explained mainly by the lower cost of a CT scan as compared with inhospital care.
To apply the results in different healthcare settings it is necessary to assess resource use separately from costs. The resource use of the two strategies (number of CT scans carried out and number of bed days consumed) is found in the data for the decision tree analysis. Application of local costs (cost of CT scan, cost of bed day) to these assumptions allows for a simple application of the findings in different settings.
The sensitivity analysis is presented in figure 2. It shows that the CT strategy yields lower costs in 78 of 81 possible situations when probabilities and costs are varied within reasonable limits. It also shows that in 27 cases the CT strategy would reduce costs more than the 36% presented in our main assumption. In three cases the costs are equal, and none show a higher cost associated with the CT strategy.
In this case, the number of patients admitted despite normal CT findings was 10%, and 20% of the patients observed received a CT scan. This means that the cost of the CT strategy would be 36% lower than that of inhospital observation (see box in figure 2).
There are no economic studies of mild head injury where actual costs are measured and compared in patients managed under the two strategies—that is, inhospital observation compared with CT to triage for admission.
Based on model calculations in four studies from two countries it seems as if a CT based strategy would consume fewer resources. The ratio between the cost of a CT scan and the cost per day and length of inhospital observation is central for our cost analysis. Our cost of illness calculations in Sweden found the ratio to be around 0.4 ( = cost of CT scan compared with the cost of average 1.4 bed days). We believe that the ratio is roughly similar throughout many industrialised countries. Of course, the applicability of a CT strategy also depends on the national structure of acute care, especially the availability of CT scanners.
The sensitivity analysis shows that within a realistic span of variation the CT strategy would be less costly. In addition, current changes in clinical practice in Sweden indicate a move towards an increase in the use of CT despite admission. Such a trend favours a CT strategy even further in regard to costs.
Lower costs with a CT strategy presume adherence to the definition of mild head injury. If previously non-admitted patients are scanned the total cost could rise. Also, the lower total costs presume that many patients with a normal CT scan will be discharged. It could also be argued that earlier diagnosis may increase costs by increasing ICU stay or surgical intervention. However, the complete opposite is also fully conceivable. A prospective randomised trial with patient follow up will be the only way to get really reliable evidence regarding the risks, benefits and costs of different management strategies for mild head injury.
In conclusion, a substantial body of indirect evidence suggests that a CT strategy for the acute care of mild head injury is resource saving.
Brain concussion; brain injuries; case reports; cerebral haemorrhage; closed head injuries; CT; diagnosis; diagnostic errors; emergency service, hospital; follow up studies; haematoma (epidural, subdural); head injuries; mild brain injury; mild head injury; minimal brain injury; minimal head injury; minor brain injury; minor head injury; monitoring, physiological; mortality; radiography; review, guidelines; risk assessment; risk factors; sensitivity, specificity; survival rate; tomography, x-ray computed; triage.
A systematic literature review was originally carried out for the Swedish Council on Technology Assessment in Health Care (SBU) and published in a Swedish governmental report in December 2000. The SBU Project Group on Mild Head Injury included Mona Britton (project chair) Jörgen Borg, Mia Colliander, Jean-Luc af Geijerstam (project coordinator), Kaj Ericson, Lars-Åke Marké, Johan Nathorst Westfelt, Sven Oredsson, and Elisabeth Ronne-Engström. This report has now been updated, shortened, and focused more on scientific aspects.
Funding: this study was supported by The Swedish Council on Technology Assessment in Health Care (SBU).
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