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More than just an ocular solution
  1. M Pekdemir1,
  2. S Yanturali2,
  3. G Karakus3
  1. 1Department of Emergency Medicine, Kocaeli Universtiy, Kocaeli, Turkey
  2. 2Department of Emergency Medicine, Dokuz Eylul University, Izmir, Turkey
  3. 3Department of Internal Medicine, Kocaeli Universtiy, Kocaeli, Turkey
  1. Correspondence to:
 Dr S Yanturali
 Dokuz Eylul University Medical School, Department of Emergency Medicine, 35340, Inciralti, Izmir, Turkey; sedat.yanturali{at}


Apraclonidine eye drop is an alpha adrenergic agonist derived topical clonidine, used for the treatment of intraocular pressure elevation. We report what is to our knowledge the first case of systemic toxicity of apraclonidine resulted from repeated local administration. Clinical manifestation of toxicity was similar to oral clonidine overdose. Toxicities of ocular drugs should always be considered when a patient presents with new systemic problems.

  • BP, blood pressure
  • ED, emergency department
  • HR, heart rate
  • IOP, intraocular pressure
  • Apraclonidine
  • adverse effect
  • ocular solution
  • overdose
  • toxicity

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  • Competing interests: none declared