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SOCRATES 10 (synopsis of Cochrane reviews applicable to emergency services)
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  1. P Gilligan1,
  2. J Jones1,
  3. A Khan1,
  4. D Hegarty2,
  5. M Shepherd1,
  6. G Lumsden1,
  7. G Kitching1,
  8. A Taylor1,
  9. H Law1,
  10. J Brenchley1
  1. 1Specialist Registrars in Emergency Medicine on The Yorkshire Rotation, UK
  2. 2General Practitioner, Leeds, UK
  1. Correspondence to:
 Dr P Gilligan
 1 Far Moss, Alwoodley, Leeds LS17 7NU, UK; hegartydeirdreireland.com

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In this, the tenth article of the SOCRATES series, we present our synopses of reviews from the Cochrane Database of Systematic Reviews relating to gastroenterology and fluid management that the working party felt were of particular relevance to emergency medicine practitioners. The methods of our review and the rationale for the forming the SOCRATES working party are as have previously been published.

HUMAN ALBUMIN SOLUTION FOR RESUSCITATION AND VOLUME EXPANSION IN CRITICALLY ILL PATIENTS

Background

The objective of this review was to quantify the effect on mortality of human albumin and plasma protein fraction in the management of critically ill patients.

Results

A total of 30 randomised controlled trials were identified. In each of the patient categories the risk of death in the albumin treated group was higher than in the placebo group. There were 156 deaths among the 1419 patients. Overall the risk of death in patients treated with albumin is 6% (95% CI 3% to 9%) higher than in patients not given albumin.

SOCRATES says

There is no evidence that albumin reduces mortality and a strong …

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