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Troponin for prediction of cardiovascular collapse in acute colchicine overdose
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  • Published on:
    Authors' response

    Dear Editor,

    We note with interest the comments on our report made by David Wood and colleagues at the Guy’s Poisons Unit. Our response to these is as follows.

    The evidence for our conclusion is obtained from the literature on troponins as well as the two case reports by Mullins and ourselves. As troponin testing is relatively new and colchicine overdose a rare event it will take many years to build up mo...

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    Conflict of Interest:
    None declared.
  • Published on:
    Serial Troponin-I measurements are unlikely to be useful in acute colchicine toxicity
    • David M WOOD, Specialist Registrar in Clinical Toxicology
    • Other Contributors:
      • Shaun L. GREENE, Paul I. DARGAN, Alison L. JONES

    Dear Editor,

    van Heyningen and Watson reported a case of acute colchicine poisoning, associated with significant cardiovascular compromise, with elevated troponin-I concentrations, resulting in death.[1] Elevation of cardiac troponin concentrations in acute colchicine toxicity has been previously reported.[2] The authors concluded that in future cases serial 12 hourly troponin measurements should be undertake...

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    Conflict of Interest:
    None declared.