Article Text

Potential cervical spine injury and difficult airway management for emergency intubation of trauma adults in the emergency department—a systematic review
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1. J E Ollerton,
2. M J A Parr,
3. K Harrison,
4. B Hanrahan,
5. M Sugrue
1. Liverpool Hospital, Sydney, Australia
1. Correspondence to:  J E Ollerton  Department of Trauma, Liverpool Hospital, Locked Bag 7103, Liverpool BC, NSW 1871, Australia; j.ollerton{at}doctors.org.uk

## Abstract

Background: Emergency airway management for trauma adults is practised by physicians from a range of training backgrounds and with differing levels of experience. The indications for intubation and technique employed are factors that vary within EDs and between hospitals.

Objectives: To provide practical evidence based guidance for airway management in trauma resuscitation: first for the trauma adult with potential cervical spine injury and second the management when a difficult airway is encountered at intubation.

Search strategy and methodology: Full literature search for relevant articles in Medline (1966–2003), EMBASE (1980–2003), and the Cochrane Central Register of Controlled Trials. Relevant articles relating to adults and written in English language were appraised. English language abstracts of foreign articles were included. Studies were critically appraised on a standardised data collection sheet to assess validity and quality of evidence. The level of evidence was allocated using the methods of the Australian National Health and Medical Research Council.

• c-spine, cervical spine
• ED, emergency department
• MERGE, method of evaluating research and guideline evidence
• MILS, manual in-line stabilisation
• NHMRC, National Health and Medical Resource Council
• RSI, rapid sequence induction and intubation
• emergency airway management
• trauma
• cervical spine
• difficult airway

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Immediate management of the compromised or “at risk” airway is crucial in trauma. Current variability in the process of airway management and intubation suggests there is need for a more consistent, evidence based approach. Physicians from a variety of backgrounds and experience undertake management of the airway in the resuscitation room.1–3 A systematic review of the literature will provide an invaluable education resource to guide airway management of trauma adults in the emergency department (ED).

Trauma adults are at particular risk of associated cervical spine (c-spine) injury with a 2–5% risk of c-spine trauma4–10 of which up to 14% will be unstable.11,12 At the time of emergency intubation in the resuscitation department the injury must often be presumed based on clinical signs and mechanism of injury. Further investigation in the form of plain radiographs, computerised tomography, and magnetic resonance imaging will provide detailed information. Criswell found 10% of blunt trauma patients with proven c-spine injury needed emergency intubation within 30 minutes of arrival in the ED.4

A variety of institutions have shown a wide range (between 9 and 41%) of trauma patients undergoing intubation,13–18 and Jaberi demonstrated 32.3% of these were within 30 minutes of arrival in the ED.13 Complications arise as a result of emergency intubations,15,19–21 but failure or delay in securing an adequate airway appear to cause unacceptably high morbidity and mortality rates.22–24 Rapid intubation when appropriate will need to minimise any movement of the c-spine with consideration of associated risks of the procedure.25–27 Complications, such as aspiration of gastric contents and the subsequent lung injury, are independent factors increasing morbidity and mortality in this group of patients28,29 and require specific techniques to minimise risk.

Difficult airway algorithms have been previously produced and implemented for use on both routine and emergency patients.30–35 Evidence based guidelines for trauma adults requiring emergency intubation in the ED have not been so widely researched. Previous reviews of the scientific literature have identified the key indications to intubate a trauma patient.18 This review aims to provide evidence based guidance for the technique of airway control in trauma adults with potential c-spine injury and to optimise patient care when a difficult airway is encountered.

## OBJECTIVES

The objectives of this study were to perform systematic reviews of the literature to provide evidence based recommendations for emergency airway management in two scenarios:

1. In the trauma adult with potential cervical spine injury requiring emergency intubation in the ED, what is the optimal technique to secure the airway? (evidence—table 1).

2. In the trauma adult requiring emergency control of the airway, what is the best treatment algorithm to follow for management of a difficult airway? (evidence—table 2).

## CRITERIA FOR INCLUSION IN THIS STUDY

Randomised controlled trials were the preferred source of evidence but in the absence of sufficient material other levels of evidence were considered. Articles relating to adults and English abstracts from relevant foreign language studies were included. Descriptive, opinion based studies, case reports, letters to the editor, and articles relating to children were excluded.

## SEARCH STRATEGY

Based on the key clinical questions above, electronic databases of Medline, Cochrane and EMBASE, using the Ovid interphase, were searched. The internet was searched using the Google search engine. The Medline search included the 1966 to September 2003 database. The EMBASE search included references from 1980 to 2003. The Cochrane Central Register of Controlled Trials was searched in September 2003. References generated from the search were assessed for relevance to the key questions by their titles and abstracts wherever possible. Relevant studies were obtained and their associated references also hand searched for inclusion. The following keywords and combinations were used. C-spine injury search: exp spinal injuries; fractures or spinal fractures; exp cervical vertebrae; exp “wounds and injuries”; emergency; exp intubation, intratracheal; anaesthesia or anaesthesia, intratracheal or anaesthesia, intravenous; rapid sequence (intubat$or induct$). Difficult airway search: exp intubation, intratracheal; difficult (airway or intubation); emergency; exp “wounds and injuries”; trauma; guidelines or recommendations or options or protocols.

## SELECTION CRITERIA AND METHODOLOGY

A working group was established prior to the onset of the study represented by all specialities involved in emergency airway management likely to be affected by implementation of the recommendations. Sixteen specialists from backgrounds of anaesthesia, trauma, intensive care, epidemiology, pre-hospital retrieval teams, and the ED were involved; both rural communities and teaching hospital environments were represented. The Cochrane Reviewers’ Handbook (available online at http://www.cochrane.org/cochrane/hbook.htm— accessed 14 November 2005) and the Cochrane Anaesthesia Review Group methods36 were used as a basis for the process of the review.

Selected studies underwent a validated method of critical appraisal on a tabulated methodology checklist;37,38 summarised data were extracted to standardised data collection tables. Studies were graded for levels of evidence according to a system recommended by the National Health and Medical Research Council (NHMRC) of Australia.39 The quality of evidence, relevance to the key question, and the strength of the evidence were factors also considered. The method of evaluating research and guideline evidence (MERGE) assessment tool38 was used to describe the degree of bias in each article undergoing critical appraisal. All papers were appraised by either a consultant epidemiologist or the first author. For purposes of validation and objectivity, 10% of the articles were re-assessed by a second physician to ensure consistency of opinion on the appraisal.

The joint expertise and experience of the working group enabled recommendations explicitly linked to the supporting evidence and graded according to the strength of that evidence (table 1). The considered judgement for each recommendation took into account the volume of evidence, applicability, generalisability to the target population, consistency of results, and the potential clinical impact of implementation.40

## SCIENTIFIC EVIDENCE

Altogether 180 articles were identified from the initial c-spine injury search of which 25 were deemed most relevant to the clinical question. With the difficult airway search, 472 articles were found of which 22 were of adequate quality and most relevant to the review. These articles are summarised in the evidence tables and recommendations listed below:

1. For adults with potential c-spine injury requiring emergency intubation in the ED, the optimal method of achieving a secure airway is Rapid Sequence Induction and Intubation (RSI) (Level B recommendation). RSI is described in Appendix A.

2. Manual in-line stabilisation (MILS) of the c-spine is the recommended technique to immobilise the c-spine (Level B recommendation). This entails firmly holding the patient either side of the head with the neck in the midline and the head on a firm trolley surface. Traction is not applied and the aim is to prevent any flexion or rotation of the c-spine when laryngoscopy is performed. To facilitate the airway specialist, the assistant needs to crouch by the trolley, slightly to one side, while intubation is performed. The cervical collar may be loosened or the anterior portion temporarily removed to facilitate mouth opening and application of cricoid pressure.4,41–47

3. A tracheal tube introducer is recommended for routine use in RSI (Level B recommendation). The tracheal tube introducer (flexible bougie or stylet) should be immediately to hand whenever RSI is undertaken. The flexible bougie is the preferred option for first-line use in all cases to maximise rates of intubation on first attempt.35,48–51

4. A selection of laryngoscope blades should be available both in size and design. The evidence supports the use of the MacIntosh and McCoy laryngoscopes (Level B recommendation).52–54

5. The laryngeal mask airway (LMA) is recommended as a temporary adjunct when endotracheal tube insertion fails (Level C recommendation). It requires some training before use and has not yet been well evaluated in the literature for use in trauma with respect to the risks of aspiration.27,35,41,55–57

6. The recommended approach to the difficult airway in the trauma adult requiring immediate intubation in the ED is illustrated in Appendix B.18,20,21,30–35,58–70

## STATEMENT ON THE EVIDENCE

RSI has become accepted standard practice for this type of patient in need of immediate intubation. Under the search strategy employed looking at emergency intubations in trauma adults there was no level I or II evidence to support this accepted technique. Much of the work to enforce RSI as the technique of choice has been in fields other than trauma, such as obstetrics. The generalisability of this data to trauma is unknown but the consensus of opinion was that data could be satisfactorily extrapolated to the trauma scenario. Sakles performed a prospective review of 610 ED intubations: 47.7% were trauma cases.21 RSI was used in 89.9% of patients (n = 515), of whom 99.2% were successfully intubated. Intubations without paralytic agents achieved a 91.5% success rate. There was a reported complication rate of 9.3%. The most common complication was desaturation (SaO2<85% in 3.2%) with no neurological deficit at discharge. The second most common complication was right main stem intubation (3.0%): none resulting in further complications.

RSI involves four experienced personnel with dedicated roles.26 Compromise on this will increase the chance of complications. Roles include i) the airway specialist to direct the procedure and intubate the patient, ii) an assistant placed to his/her left hand side, at the head of the bed to provide MILS, iii) a second assistant to provide cricoid pressure with their right hand and assist the specialist with equipment from the patient’s right hand side, iv) a third assistant to administer intravenous induction agents. There are clinical implications in the resources required as a result of this recommendation. The described technique ensures a speedy, safe intubation and sufficient staffing levels should be routinely maintained in any department receiving trauma patients. Airway training issues are beyond the scope of this study to consider but reinforcement of practical skills in airway management is imperative.

A full anaesthetic history and assessment is recommended whenever the situation allows.25,71,72 The AMPLE history has been described and is a good routine to follow.73 This includes history of allergies, medications, the past medical history, timings of the last meal, and the events leading to the anaesthetic. Assessment of the Mallampati score74 may be possible but is often limited by the urgency of the situation, a supine patient, and limited mouth opening because of the cervical collar.41,49 Anatomical variations contribute to the prediction of a “difficult airway” and include a small chin, obesity, large tongue, protruding dentition, and a high arched palate in addition to any associated injury to the head and neck. Carley reviews airway assessment and scoring systems used to predict difficult intubation in more detail and with direct relevance to the trauma patient.75

Oral endotracheal intubation is the technique of choice. Techniques such as BURP (Backwards, Upwards and Right Pressure) may supplement cricoid pressure if the vocal cords are not immediately visualised on laryngoscopy.76–81 Cricoid pressure is described in Appendix C. Brimacombe demonstrated that fiberscope guided nasotracheal intubation caused the least amount of cervical movement.82 In contrast, Donaldson showed no advantage of nasal intubation over oral tracheal intubation in terms of cervical movement.47 Smith found the fiberoptic laryngoscope was associated with lower intubation difficulty and better views of the laryngeal structures when compared with conventional laryngoscopy;83 however, no benefit was demonstrated on success of intubation or number of attempts to intubation.

For cooperative patients and when the clinical situation allows, there may be time to recruit further resources and hence alternative options for achieving a secure airway, including awake intubation and fibreoptic techniques.83–85 This review concentrates on those trauma adults requiring immediate airway control in the ED, which will limit these options. The use of fiberscope guided intubation in the ED is generally not feasible because of availability of fibreoptic equipment in emergent situations and practitioners experienced in its use.

Basic physiological monitoring should not be a compromise from requirements elsewhere in the hospital (heart rate, pulse oximetry, capnography, non-invasive blood pressure, and cardiac monitor (electrocardiogram)) (Table 2),86,87 and confirmation of correct tube placement should include the measures described at Appendix A.

Several studies address the optimal method to immobilise the c-spine. A subsection of these are cadaveric studies, but all results appear to be consistent with good generalisability to our target population. When considering the degree of c-spine movement in most studies it is notable that no definition of a ‘safe’ amount of movement has been set.44–47,82,88,89

In a non-randomised trial, Heath evaluated the effect of rigid cervical collar, tape across the forehead, and sandbags either side of the neck versus manual in-line immobilisation on view at laryngoscopy.46 He demonstrated poor views on laryngoscopy (grade 3 or 4) in 64% of patients immobilised in a collar, tape, and sandbags compared with 22% with the application of MILS (p<0.001). Nolan demonstrated MILS reduced laryngeal views by 45% with nothing visible beyond the epiglottis in 22% of patients.49 Majernick showed MILS resulted in less cervical subluxation and allowed better vocal cord visualisation compared with immobilisation in a rigid cervical collar.45 Gerling’s randomised crossover trial on 14 cadavers demonstrated least c-spine movement when MILS was employed rather than sandbags and tape.43 Lennarson also demonstrated the benefit of MILS in his crossover trial on 10 cadavers with destabilised c-spine when compared with Gardner-Wells traction or no immobilisation during intubation.44

Nolan performed a randomised trial of 157 elective patients intubated with MILS and cricoid pressure using either the endotracheal tube (ETT) alone or with a gum elastic bougie.49 The group in whom the bougie was used had more successful intubations and no extra time taken to intubation. Gataure compared the bougie and stylet in intubation scenarios with simulated grade 3 views of the glottis. He demonstrated higher success rates of intubation with the bougie than with the stylet (96% v 66%).48

With regards to the choice of laryngoscope, Watts compared the Macintosh and Bullard laryngoscopy blades.52 The Bullard laryngoscope with MILS in situ resulted in less cervical spine extension (5.6+/− 1.5 degrees) than the Macintosh blade (12.9+/− 2.1 degrees). The time taken to intubate with the Bullard laryngoscope was longer (20.3+/− 12.8 s v 40.3+/− 19.5 s; p<0.05). The Bullard laryngoscope may be of benefit when the need for intubation is not time critical. Studies evaluating the McCoy laryngoscope have been conflicting.53,54,90

There is no evidence to state the optimal number of intubation attempts before alternative techniques to secure the airway are adopted. Similarly there is limited evidence to directly compare equipment for specific conditions. Such evidence is unlikely to become rapidly available because of the highly variable conditions encountered with patients, their injuries, the clinical situation, and the operator managing the airway. Randomised clinical trials in this scenario have inherent difficulties in design and large numbers are required to enable comparison between groups.

Equipment options for consideration in airway control are varied and will depend on operator experience and skill. The literature considers various techniques and equipment with the oral ETT declared optimal. Brimacombe demonstrated the LMA was comparable to endotracheal intubation in terms of success and time to placement,56 but Keller showed the LMA caused greater posterior displacement of the cervical vertebrae.88 Brimacombe’s cadaveric study found similar displacement of the cervical vertebrae with the LMA and ETT (1.7+/− 1.3 mm for LMA v 2.6+/− 1.6 mm for ETT).82 Differing techniques used to measure this displacement may explain the conflicting results. Keller used microchip pressure sensors in an intact spine whereas Brimacombe used continuous lateral fluoroscopy in the presence of a posteriorly destabilised third cervical vertebra. The LMA has proven usefulness as an airway in fasting patients undergoing anaesthesia but its role in management of the difficult airway and the traumatic airway is still evolving. The LMA does not protect against aspiration27 and cannot be recommended for first line management of the airway in trauma patients. Its use as an emergent airway when conventional techniques fail is recommended. Alternative equipment such as the combitube, intubating laryngeal mask, lighted stylet, and jet ventilation of the trachea may have a role in some institutions but are not recommended over the options described here.18,31,57–65,85,91

Difficult airway algorithms for use in an emergency situation have been previously formulated30–32,34 but few are aimed specifically at the trauma scenario that presents specific challenges.18 Few algorithms published are based on systematic reviews of the literature but formulated by consensus opinion of experts in the field biased by their own working environment. Crosby and the Eastern Association for the Surgery of Trauma (EAST) reviewed the literature but restricted their searches to the Medline database.18,31 The Difficult Airway Society published an airway management algorithm relevant to RSI on their website—potential c-spine injury and the trauma patient were not specifically considered. This guideline has recently been published and addresses the unanticipated difficult airway in different scenarios.34 It was formulated from consensus opinion of specialists and evidence from a Medline search, generally, reinforcing the recommendations produced in this review.

A key feature in the algorithm in Appendix B is the use of oxygen saturation to assess adequacy of ventilation and hence represent end organ tissue perfusion and oxygenation. This has room for error. Oxygen saturation monitoring by pulse oximetry using a light emitting diode attached to a digit, ear, or nose has recognised limitations.92,93 Particularly relevant to trauma, these include poor signal because of peripheral vasoconstriction related to hypovolaemia, cold, or pre-existing peripheral vascular disease. Dependence on this measurement alone as a measure of ventilation must therefore be used with utmost caution.

The end point of the algorithm to achieve a definitive airway is surgical cricothyroidotomy—an open technique requiring a surgical blade (size 11) and a size 6 cuffed ETT. Further details on technique are beyond the scope of this study but available in most good trauma texts. The literature suggests cricothyroidotomy rates of 2–3% in patients requiring emergency airway control in the ED (actually ranging between 0.3 and 12.4%).13,21,66,67,94–97 This is between 0.01 and 1.1% of the total number of ED admissions.13,21,67,95–97 Hawkins’ retrospective review of 5603 trauma patients concluded cricothyroidotomy was feasible and safe with a risk of minor complications.96 Cricothyroidotomy is a procedure to be undertaken quickly and decisively without unnecessary extra attempts at intubation; this algorithm should prompt timely effective intervention in trauma patients with a difficult airway.

The difficult airway algorithm resulting from this search was formulated after lengthy debate and consideration of the supporting evidence by the working group. It provides simple, uncomplicated methodology in a single page flow chart. The recommendations for difficult airway management are appropriate to all skill levels and ED environments. The clinical impact of the algorithm should therefore be significant with minimal additional resource implications.

## SUMMARY

There is limited evidence pertaining directly to airway management in trauma adults and further clinical trials are required to provide evidence directly relevant to this group of patients to reinforce the recommendations provided. These recommendations are intended for use by all clinicians involved in airway management of trauma patients presenting to the ED. Extrapolation to other clinical situations, such as the operating theatre and pre-hospital environment, may be relevant but have not been specifically evaluated in this search. Clinicians must assess each patient on individual merit, which, together with consideration of their own skill level and experience, will enable them to use these evidence based recommendations in providing optimal patient care. Implementation of these guidelines will enable evaluation of the recommendations and amendment as appropriate.

## APPENDIX A RAPID SEQUENCE INDUCTION/INTUBATION (RSI) IN TRAUMA

PURPOSE

To achieve a secure airway—that is, a cuffed tube in the trachea—while minimising the risk of aspiration of gastric contents in high risk individuals.

THEORY

Induction of anaesthesia with a rapid onset sedating agent and neuromuscular blocking agent, application of cricoid pressure, and intubation of the trachea with an oral, cuffed endotracheal tube (ETT).

METHOD

1. Check equipment, draw up drugs, and label syringes. Place wall suction under the pillow by your right hand and ensure a tracheal tube introducer is immediately available. Allocate staff roles (four experienced personnel required).

2. Pre-oxygenate patient for up to 5 minutes or as long as circumstances allow.

3. Loosen or remove anterior portion of the hard cervical collar while maintaining an immobile cervical spine with manual in-line stabilisation of the neck (MILS).1

4. Rapid administration of induction agent through peripheral venous line with flush, followed by neuromuscular blocking agent and flush.

5. Application of cricoid pressure as anaesthesia is induced.2

6. When muscle fasciculation has stopped, there is other objective evidence of paralysis, or after 60 seconds, perform laryngoscopy and intubate the trachea.3,4

7. Inflate the ETT cuff and check position of the tube by capnography, visualisation of chest movements, auscultation of bilateral axillae and epigastrium, and observation of patient monitoring.5 Secure the ETT.

8. Remove cricoid pressure after confirmation of tracheal intubation with cuff inflation and following instruction from the intubating physician.

9. Insert naso/orogastric tube.

10. Obtain a CXR to confirm tube position.

REQUIREMENTS

• Four trained staff

• Tight fitting transparent face mask

• High flow oxygen

• Self inflating bag and mask (selection of sizes)

• Selection of laryngoscopes, blades, and spare bulbs

• Selection of ETT

• Tracheal tube introducer (bougie or stylet)

• Selection of oropharyngeal airways

• Selection of laryngeal mask airways

• Continuous monitoring of heart rate and non-invasive blood pressure

• Pulse oximetry

• Capnography

• Wall suction immediately available

• Tie to secure airway

• Drugs drawn up in pre-determined doses

• Saline flush

NOTES

1. MILS technique is described in the main text.

2. Cricoid pressure technique described at Appendix C.

3. Objective evidence may include use of a nerve stimulator.

4. It is recommended that a flexible bougie is always used in the trauma patient. As a minimal requirement it should be at the right hand of the operator during intubation attempts. A stylet is an optional adjunct.

5. Failure to correctly place the ETT should prompt the operator to follow the “difficult airway algorithm” provided in Appendix B.

## APPENDIX B DIFFICULT AIRWAY ALGORITHM

Figure 1

1. Reliance on oxygen saturations has limitations and is a guide only to be taken in clinical context. 2. Intubating or standard LMA is an option if the operator is experienced in its use. Other options may include light wand, fibreoptic intubation, combitube, nasal and blind oral intubation if experience is available. If these are not options the surgical cricothyroidotomy should be performed immediately. *MILS, manual in-line stabilisation of the cervical spine; **BURP, backwards, upward, right pressure to the thyroid cartilage to facilitate laryngeal views.

## APPENDIX C CRICOID PRESSURE

PURPOSE

• Prevention of gastric regurgitation

• Prevention of gastric insufflation during ventilation

• Aid to intubation

THEORY

Avoiding extension of the neck apply backward pressure on the cricoid cartilage. This complete cartilaginous ring transmits pressure to compress the upper oesophagus against the 5th vertebral body. Occlusion of the oesophagus prevents regurgitation of gastric contents and aspiration.

METHOD

• In conscious patients the cricoid cartilage is palpated between the thumb and middle finger, with the index finger above.

• The cricoid cartilage is located just below the prominent thyroid cartilage (Adam’s apple).

• As anaesthesia is induced the pressure is increased in a vertical plane onto the vertebral body of C5.

• The amount of pressure needs to approximate to 30 Newtons—comparable to the pressure that would feel uncomfortable if applied to the bridge of the nose.

• Removal of cricoid pressure should only follow securing of the airway and the request of the person performing intubation.

PROBLEMS

1. Cricoid pressure may increase the difficulty of intubation, usually because of incorrect placement. The pressure needs to be applied in the vertical plane in the supine patient to avoid causing tracheal and laryngeal deviation. On request it may be necessary to adjust position or rarely remove cricoid pressure to facilitate intubation.

2. If vomiting occurs it will be necessary to release cricoid pressure. Always ask if you want to remove cricoid pressure and have not been requested to do so.

Table 1

In the adult with potential cervical spine injury requiring emergency intubation in the resuscitation room, what is the optimal method to achieve a secure airway? Evidence from systematic reviews of the literature

Table 2

In the trauma adult requiring emergency control of the airway, what is the best treatment algorithm to follow for management of a difficult airway? Evidence from systematic reviews of the literature

Table 3

## Footnotes

• Funding: none.

• Competing interests: none declared.