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Cardiotoxicity is an uncommon adverse effect of 5-FU treatment. Prevalence of 5- fluorouracil (FU) - induced cardiotoxicity is 2–18%, and represents an interesting clinical challenge.1 A 62 year old male was admitted to our emergency department with severe dyspnea, chest pain, diaphoresis, nausea, and pruritis after the completition of a regimen of 5-FU chemotherapy for gastric adenocarcinoma. The ECG showed sinus tachycardia and global ST segment elevation in all leads except in DIII, aVR and V1 (Fig 1). Chest pain and ECG changes resolved at 30th minute of the nitroglycerin infusion with the dose of 60 μg per minute. Coronary angiography has not demonstrated any pathology.
The patient was discharged on medical therapy including ASA, amlodipine 5 mg, atorvastatin 10 mg. He has been symptom-free for six months.