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National Poisons Information Service (NPIS) guidelines for the treatment of paracetamol overdose recommend the use of intravenous N-acetylcysteine (NAC) in a dose calculated according to body weight (kg). Available on Toxbase (http://www.spib.axl.co.uk). We recently treated a 180 kg patient who had overdosed on paracetamol, prompting us to question this guidance.
Paracetamol overdose is the most common method of deliberate self-poisoning in the UK. …
RD made the initial query and wrote the letter. GC made the formal enquiries leading to the change in guidelines. BP has edited the letter and acts as guarantor.
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