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Allergy evaluation after emergency treatment: anaphylaxis to the over-the-counter medication clobutinol
  1. Cornelia S Seitz,
  2. Eva-B Bröcker,
  3. Axel Trautmann
  1. Department of Dermatology, Venerology and Allergology, University of Würzburg, Würzburg, Germany
  1. Correspondence to:
 MrA Trautmann
 Department of Dermatology, Venerology and Allergology, University of Würzburg, Josef Schneider Strasse 2, D-97080 Würzburg, Germany; trautmann_a{at}


Anaphylaxis is traditionally diagnosed and treated as an acute emergency but should be always followed by a search for specific triggers, resulting in avoidance strategies. This case report highlights the relevance of a detailed evaluation after anaphylaxis for diagnosis of a rare but potentially life-threatening allergy. Considering the high frequency of clobutinol application, IgE-mediated allergic hypersensitivity seems extremely rare and has to be distinguished from infection-associated urticaria and angioedema as well as non-specific summation effects. Accidental re-exposure has to be strictly avoided and therefore after identification of clobutinol as the anaphylaxis trigger, the patient received detailed allergy documents including international non-proprietary and trade names of the culprit drug.

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  • Competing interests: None.

  • Informed consent was given by the patient for publication of his details in this report.