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Dolasetron overdose resulting in prolonged QTc interval and severe hypotension: a case report and literature review
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  • Published on:
    Response to Page et al

    Dear Editor

    We read with interest the letter by Page et al and acknowledge some important points.

    1. The heart rate-corrected QT interval (QTc) is the traditional method of assessing the duration of repolarization. However, the QTc maybe misleadingly prolonged when QRS duration is 120 ms, because increased QRS duration (QRSd) contributes to QT interval prolongation. The rate- corrected JT interval (JTc)...

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    Conflict of Interest:
    None declared.
  • Published on:
    Dolasetron and QT Interval
    • Colin B Page, Toxicology Fellow
    • Other Contributors:
      • Geoffrey K Isbister

    Dear Editor

    We read with interest the case report by Rochford et al. However, we are concerned that the title associates dolasetron overdose with a prolonged QTc despite electrocardiogram (ECG) and clinical features that are more consistent with sodium channel blockade and QRS widening.

    1.The ECG presented in the figure demonstrates the characteristic features of sodium channel blockade with a markedly...

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    Conflict of Interest:
    None declared.