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Chronic valproic acid intoxication: reversal by naloxone
  1. H K R Thanacoody
  1. Correspondence to:
 Dr H K R Thanacoody
 Scottish Poisons Information Bureau, Royal Infirmary Edinburgh, 51 Little France Crescent, Edinburgh, UK; ruben.thanacoody{at}


A 76-year-old woman being treated with sodium valproate for bipolar depression presented with a 4 day history of acute confusion and tremulousness. She had apnoeic episodes, reduced conscious level and generalised myoclonic movements. Her plasma valproate concentration was 848 µmol/l (normal 300–600 µmol/l). Administration of naloxone 0.8 mg led to rapid clinical improvement. Naloxone may be useful in reversing the features of chronic valproate toxicity.

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  • Competing interests: None declared.