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Best Evidence Topic reports
1221
BET 1: Blood component therapy in trauma patients requiring massive transfusion
  1. Andrew R Munro1, Staff Specialist,
  2. Craig Ferguson2, Specialist Registrar
  1. 1
    Coffs Harbour Base Hospital Emergency Department NSW Australia and Nelson Hospital Emergency Department New Zealand
  2. 2
    Manchester Royal Infirmary, Manchester, UK

http://dx.doi.org/10.1136/emj.2009.087502

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    Report by: Andrew R Munro,1 Staff Specialist

    Search checked by: Craig Ferguson,2 Specialist Registrar

    Institutions: 1Coffs Harbour Base Hospital Emergency Department NSW Australia and Nelson Hospital Emergency Department New Zealand

    2Manchester Royal Infirmary, Manchester, UK

    A short-cut review was carried out to establish whether there is evidence to show that 1:1:1 component therapy reduces mortality in patients who require massive transfusion after trauma. 567 papers were found using the reported searches, of which 11 presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are shown in table 1. It is concluded that early use of 1:1:1 component therapy is supported by the best available literature.

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    Table 1

    Blood component therapy in trauma patients requiring massive transfusion

    Three-part question

    In [trauma patients …

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    Footnotes

    • Provenance and Peer review Commissioned; not externally peer reviewed.