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Diltiazem overdose: a role for high-dose insulin
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  • Published on: 29 April 2016
    Intravenous lipid emulsion for calcium channel blocker overdose: fattening up the treatment
    • Theophilus L Samuels, Anaesthetic Research Registrar
    • Other Contributors:
      • David R Uncles (Consultant Anaesthetist), Johann W Willers (Associate Specialist in Anaesthesia), and Aikaterini Papadopoulou (CT2 Trainee in Anaesthesia)

    We read with interest the case report by Abeysinghe and colleagues reporting hyperinsulinaemic euglycaemic therapy (HIET) in the treatment of a patient presenting with persistent hypotension following an overdose of the lipophilic calcium channel blocker diltiazem.[1]

    Diltiazem is extremely lipophilic with a log P value of 4.53 (a measure of lipid solubility). Thus we consider that it would have been amenable t...

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    Conflict of Interest:
    None declared.