Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
What's the best vasopressor in septic shock?
Report by: Amery Robinson, Emergency Medicine Resident
Search checked by: Jeffrey Jones, Research Director, EM Residency Program
Institution: Grand Rapids Medical Education and Research Center, Grand Rapids, Michigan, USA
For [adult patients presenting to the emergency department or the intensive care unit] do [epinephrine, dopamine, dobutamine, or vasopressin] produce better [28 and 90 day mortality rates] than norepinephrine alone?
A 74-year-old female presents from a nursing home with altered mental status and recent diagnosis of pneumonia. She is febrile, tachypnoeic, tachycardic, anuric, and has a blood pressure of 72/35. Your attending physician suggests you start her on an infusion of norepinephrine; however, epinephrine has more inotropic effect. You wonder what is the best vasopressor for your patient?
Medline 1950—3/10 using Ovid interface, Cochrane Library (2010), PubMed clinical queries
[(exp shock, septic/drug therapy) AND (exp vasocontrictor agents or vasopressors.mp)] Limit to human and English.
Trials were excluded if they were not designed to investigate mortality but rather surrogate measures such as blood pressure and cardiac index. A total of …
Competing interests None.