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Best evidence topic reports
BET 3

https://doi.org/10.1136/emj.2010.107664

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    Rapid tranquilisation in acute psychotic agitation

    Report by: Lawrie Hughes, Student, Dr Gordon Fuller, Academic Clinical Fellow

    Search checked by: Dr Gordon Fuller, Academic Clinical Fellow

    Institution: Manchester Royal Infirmary, Manchester, UK

    Three-part question

    In (adult patients agitated secondary to acute psychosis) is (IM olanzapine or IM haloperidol) better at (providing safe and effective sedation)?

    Clinical scenario

    An agitated 24-year-old patient with a history of schizophrenia enters the emergency department, and becomes aggressive and hostile towards staff and patients. De-escalation techniques fail, and the patient will not take oral medication or allow intravenous cannulation. You wonder whether intramuscular (IM) haloperidol or olanzapine is the best drug to rapidly, safely and effectively calm the patient.

    Search strategy

    Medline 1950 to October week 2 2010 using the OVID interface, EMBASE 1980 to week 24 2010 using …

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    Footnotes

    • Linked articles 97279, 107474, 107656, 107672.

    • Provenance and peer review Not commissioned; not externally peer reviewed.

    Linked Articles

    • Best evidence topic reports
      Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary
      Simon D Carley
      Emergency Medicine Journal 2010; 28 74-74 Published Online First: 20 Dec 2010. doi: 10.1136/emj.2010.107474
    • Best evidence topic reports
      BET 2
      BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine
      Emergency Medicine Journal 2010; 28 75-76 Published Online First: 20 Dec 2010. doi: 10.1136/emj.2010.107656
    • Best evidence topic reports
      BET 1
      BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine
      Emergency Medicine Journal 2010; 28 74-75 Published Online First: 20 Dec 2010. doi: 10.1136/emj.2010.097279
    • Best Evidence Topic reports
      BET 4
      BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine
      Emergency Medicine Journal 2010; 28 78-81 Published Online First: 20 Dec 2010. doi: 10.1136/emj.2010.107672