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Rapid tranquilisation in acute psychotic agitation
Institution: Manchester Royal Infirmary, Manchester, UK
In (adult patients agitated secondary to acute psychosis) is (IM olanzapine or IM haloperidol) better at (providing safe and effective sedation)?
An agitated 24-year-old patient with a history of schizophrenia enters the emergency department, and becomes aggressive and hostile towards staff and patients. De-escalation techniques fail, and the patient will not take oral medication or allow intravenous cannulation. You wonder whether intramuscular (IM) haloperidol or olanzapine is the best drug to rapidly, safely and effectively calm the patient.
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