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BET 3: RIFLE criteria versus Acute Kidney Injury Network (AKIN) criteria for prognosis of acute renal failure

Abstract

A short-cut review was performed to evaluate whether the RIFLE or AKIN score for acute renal impairment is the best way to determine prognosis. A database search identified 11 relevant publications and the study methods and results were detailed in a table. The clinical bottom line is that both score are as good as predicting death following presentation with acute renal failure.

  • Clinical
  • diagnosis
  • management
  • methods
  • pulmonary embolism
  • respiratory
  • thromboembolic disease

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Reported by: Will Bentley, Medical Student

Checked by: Kerstin Hogg, Thrombosis Research Fellow

Institution: Manchester Royal Infirmary, Manchester, UK

Three-part question

In (patients presenting to the emergency department with acute renal failure) is it better to use the (RIFLE or AKIN score) to (predict prognosis)?

Clinical scenario

A 70-year-old woman presents to the emergency department (ED) with confusion and collapse. You find her serum creatinine is 180 μmol/l and wonder which classification system you should use to determine her renal function and prognosis.

Search strategy

Medline 1996 to July week 1 2011 and Embase 1947 to July 2011 using the OVID interface. ((RIFLE.mp) AND (acute kidney injury network.mp OR AKIN.mp)).

Search outcome

The Medline search identified 36 potentially relevant papers and EMBASE identified 65 papers.

Comment

No study has assessed the utility of either score in the ED. Most studies did not apply the urine output criteria, which would be more relevant to the ED population.

Clinical bottom line

Both the RIFLE and AKIN score are predictive of inpatient mortality, and appear to be equally as good.

▶ Ando M, Mori J, Ohashi K, et al. A comparative assessment of the RIFLE, AKIN and conventional criteria for acute kidney injury after hematopoietic SCT. Bone Marrow Transplant 2010;45:1427–34.

▶ Bagshaw S, George C, Bellomo R; for the ANZICS Database Management Committee. A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients. Nephrol Dial Transplant 2008;23:1569–74.

▶ Chang C, Lin C, Tian Y, et al. Acute kidney injury classification: comparison of AKIN and RIFLE criteria. Shock 2010;33:247–52.

▶ Englberger L, Suri R, Li Z, et al. Clinical accuracy of RIFLE and Acute Kidney Injury Network (AKIN) criteria for acute kidney injury in patients undergoing cardiac surgery. Crit Care 2011;15:R16.

▶ Silva Júnior G, Abreu K, Mota R, et al. RIFLE and Acute Kidney Injury Network classifications predict mortality in leptospirosis-associated acute kidney injury. Nephrology 2011;16:269–76.

▶ Haase M, Bellomo R, Matalanis G, et al. A comparison of the RIFLE and Acute Kidney Injury Network classifications for cardiac surgery—associated acute kidney injury: a prospective cohort study. J Thorac Cardiovasc Surg 2009;138:1370–6.

▶ Joannidis M, Metnitz B, Bauer P, et al. Acute kidney injury in critically ill patients classified by AKIN versus RIFLE using the SAPS 3 database. Intensive Care Med 2009;35:1692–702.

▶ Lopes J, Fernandes P, Jorge S, et al. Acute kidney injury in intensive care unit patients: a comparison between the RIFLE and the Acute Kidney Injury Network classifications. Crit Care 2008;12:R110.

▶ Ostermann M, Chang R. Challenges of defining acute kidney injury. Q J Med 2011;104:237–43.

▶ Robert A, Kramer R, Dacey L, et al. Cardiac surgery-associated acute kidney injury: a comparison of two consensus criteria. Ann Thorac Surg 2010;90:1939–43.

▶ Yan X, Jia S, Meng X, et al. Acute kidney injury in adult postcardiotomy patients with extracorporeal membrane oxygenation: evaluation of the RIFLE classification and the Acute Kidney Injury Network criteria. Eur J Cardiothorac Surg 2010;37:334–8.

Table 2

Steroid therapy in the treatment of intractable hyperemesis gravidarum

Footnotes

  • Linked articles 200635, 200636.

  • Provenance and peer review Commissioned; internally peer reviewed.

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