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  1. Rebecca Whiticar,
  2. Jonathan Wyatt
  1. Correspondence to Jonathan Wyatt; UK; production.jme{at}

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Prehospital tirofiban

Sophia read with interest a recently published substudy of the ongoing Tirofiban in Myocardial Infarction trial 2, (On-TIME 2). The objectives of the substudy were to assess whether prehospital initiation of high dose tirofiban in addition to high dose clopidrogrel resulted in a more adequate inhibition of platelet aggregation and a better clinical outcome after primary PCI. The authors conclude that even after pre-treatment with high-dose clopidogrel and aspirin for up to 2 h, platelet aggregation inhibition was significantly higher when high-dose tirofiban was added to the regime. The level of platelet aggregation inhibition was related to reduced residual ST segment deviation one hour after PCI (Heart 2010;96:1815–20).

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