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Guidelines in Emergency Medicine Network (GEMNet): guideline for the management of tricyclic antidepressant overdose
  1. Richard Body,
  2. Tom Bartram,
  3. Fawad Azam,
  4. Kevin Mackway-Jones
  1. Emergency Department, Manchester Royal Infirmary, Manchester, UK
  1. Correspondence to Richard Body, Emergency Department, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK; rbody{at}


  • The Guidelines in Emergency Medicine Network (GEMNet) has been created to promote best medical practice in a range of conditions presenting to emergency departments (EDs) in the UK.

  • This guideline presents a summary of the best available evidence to guide the management of adult patients who present to the ED following an overdose of tricyclic antidepressant agents (TCA).

  • The document has been developed following discussion among emergency physicians to decide which topics would benefit from the development of clinical guidelines.

  • The document is intended as a guideline for use in the ED by emergency physicians and is based on the review of the best existing evidence for the diagnostic tools and treatments used in this setting.

  • The document is summarised as a clinical decision support guideline that has been presented as an easy to follow algorithm.

  • The intention is for each guideline to be updated and reviewed as further evidence becomes available. The formal revision date has been set at 5 years from publication, although the guideline is subject to continuous informal review.

  • Poisoning
  • tricyclic antidepressants
  • overdose
  • guideline
  • clinical management
  • mental health
  • prehospital care
  • toxicology
  • management, emergency department management
  • mental health, overdose
  • prehospital care, clinical management

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  • Funding Funding for the development of this guideline was received from the College of Emergency Medicine, London, UK.

  • Provenance and peer review Not commissioned; not externally peer reviewed.