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Theme: Ketamine use and abuse
  1. Michael Davey1,2
  1. 1Emergency Department, Royal Adelaide Hospital, Adelaide, South Australia
  2. 2Division Acute Care Medicine, University of Adelaide, South Australia
  1. Correspondence to Dr Michael Davey, Emergency Department, Royal Adelaide Hospital, Adelaide, South Australia; michael.davey{at}

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Question 1

Which of the following are true regarding the pharmacokinetics and pharmacodynamics of ketamine?

  1. It may be administered therapeutically orally, intravenously, intramuscularly, subcutaneously, transrectally, intrathecally, intra-articularly, intranasally and transdermally.

  2. The ketamine-induced cataleptic state is typically accompanied by nystagmus with pupillary dilation, salivation, lacrimation, and spontaneous limb movements with increased overall muscle tone.

  3. Ketamine is hepatically metabolised.

  4. Ketamine has a small volume of distribution and slow clearance making it less suitable for continuous infusion.

Question 2

Which of …

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  • Provenance and peer review Not commissioned; internally peer reviewed