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Diagnostic performance of mean platelet volume for patients with acute coronary syndrome visiting an emergency department with acute chest pain: the Chinese scenario
  1. Hsin Chu1,2,
  2. Wei-Lung Chen3,4,5,
  3. Chien-Cheng Huang3,4,
  4. Hsin-Yu Chang3,
  5. Hung-Yi Kuo3,
  6. Chorng-Ming Gau6,
  7. Yue-Cune Chang7,
  8. Ying-Sheng Shen1,3,4
  1. 1Institute of Aerospace Medicine, School of Medicine, National Defense Medical Center, Taipei, Taiwan
  2. 2Department of Neurology, Tri-Service General Hospital, Taipei, Taiwan
  3. 3Department of Emergency Medicine, Cathay General Hospital, Taipei, Taiwan
  4. 4School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan
  5. 5Institute of Traditional Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
  6. 6Department of Clinical Pathology, Cathay General Hospital, Taipei, Taiwan
  7. 7Department of Mathematics, Tamkang University, Taipei, Taiwan
  1. Correspondence to Dr Ying-Sheng Shen, Department of Emergency Medicine, Cathay General Hospital, No. 280 Sec 4, Jen-Ai Rd, Taipei, Taiwan; yingsheng1024{at}


Objectives To assess the ability of mean platelet volume (MPV) to detect acute coronary syndromes (ACS) in Chinese patients within 4 h of chest pain onset.

Methods Consecutive adult Chinese patients who arrived at an emergency department (ED) with acute chest pain (onset within 4 h) between May and August 2009 were recruited. The MPV was checked for all enrolled patients on arrival at the ED, and further comparisons between the patients in different groups were made.

Results 282 patients (136 men and 146 women) were enrolled and 69 were diagnosed as having ACS (24.5%). As compared with the non-ACS group, the ACS group had significantly higher MPV values (10.8±0.86 fl vs 9.8±0.76 fl, p<0.001). Moreover, we found that the MPV values were higher in patients with acute myocardial infarction (AMI) (n=28) as compared with patients with unstable angina (UA) (n=41) (11.0±0.79 fl vs 10.6±0.87 fl, p=0.027). Multiple logistic regression analysis yielded the fact that the initial MPV was an independent predictor of ACS attack in patients with acute chest pain (OR 8.866). The corresponding area under the receiver operating characteristic curve (ROC) for MPV in predicting ACS in patients with acute chest pain was 0.800 (95% CI 0.736 to 0.864) and the best cut-off value was 10.35 fl (sensitivity 78.3%; specificity 74.6%).

Conclusions MPV is significantly associated with ACS in patients with acute chest pain and is an early and independent predictor.

  • Mean platelet volume
  • cardiac care
  • acute coronary syndromes
  • acute myocardial infarction
  • troponin I

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  • Funding This study was supported in part by grant no. DOD98-01-03 from the National Defense Medical Center.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Institutional Review Board of Cathay General Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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