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Response to the recent best evidence topic on the use of thrombolysis in stroke
  1. Daniel M Fatovich
  1. Correspondence to Daniel M Fatovich, Department of Emergency Medicine, Royal Perth Hospital, University of Western Australia, Centre for Clinical Research in Emergency Medicine, Perth, Western Australia 6847, Australia; daniel.fatovich{at}

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The letters by Kaye and Ferguson highlight some issues in the controversy on this subject.1 However, it is important to look at the totality of the evidence in more detail. The most recently published independent review on this subject concluded that ‘there is no consistent or proven benefit to thrombolytics.’2 This review also highlights the problems with the pooled analyses, which have been incorrectly labelled as a ‘meta-analysis’ in …

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