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Early out-of-hospital non-invasive ventilation is superior to standard medical treatment in patients with acute respiratory failure: a pilot study
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  • Published on:
    How can one claim 'superiority' in a pilot study

    I enjoyed reading the paper by Markus S?ren Roessler and colleagues, but wondered how a claim for superiority could be made on the basis of a pilot study?

    Conflict of Interest:

    None declared

    Conflict of Interest:
    None declared.
  • Published on:
    Re:Out-of- hospital non-invasive mechanical ventilation: discovering a new setting.
    • Markus Soren Roessler
    • Other Contributors:
      • Peter Michels, Oliver Schmid, Klaus Jung, J?rg St?ber, Peter Neumann, Michael Quintel, Onnen Moerer

    We thank Antonio Esquinas for his response to our article. Our rationale for NIV in the prehospital setting is based on the pathophysiology of acute respiratory failure. In acute hypoxic respiratory failure shunt is the primary underlying problem. While the application of Oxygen (+ specific medication, e.g. diuretics) may improve SpO2, the paO2/FiO2- Index will not improve, as there is no alveolar recruitment. NIV immedia...

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    Conflict of Interest:
    None declared.
  • Published on:
    Out-of- hospital non-invasive mechanical ventilation: discovering a new setting.

    Title: Out-of- hospital non-invasive mechanical ventilation: discovering a new setting.

    Antonio M. Esquinas MD, PhD, FCCP International Fellow AARC Intensive Care Unit Hospital Morales Meseguer Avenida Marques de los velez s/n Murcia, 3008 Spain Phone:+34609321966 FAX:+34968232484 E-mail:

    Key words: non invasive mechanical ventilation; out-of-hospital.

    To editor:...

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    Conflict of Interest:
    None declared.