• Troponin
• high sensitivity troponin
• acute myocardial infarction
• acute coronary syndrome

Carlton and Greaves1 raise some important issues in response to our recent article1a regarding the implications of implementing high sensitivity troponin assays and other risk scores for investigation of patients with acute coronary syndromes.

The aim of evaluation of patients with possible acute coronary syndrome in the Emergency Department is to identify whether patients require admission (to inpatient care or observation unit depending on hospital facilities). As patients with missed acute coronary syndrome (ACS)/acute myocardial infarction (AMI) are at a higher risk of adverse events,2 strategies used to identify those not requiring admission require high sensitivity and negative predictive value. As a highly sensitive tool for the diagnosis of AMI, high sensitivity cardiac troponin (hs-cTn) is appealing for this task.3–5 Although …