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BET 3: In well-appearing children suspected of meningococcal disease can procalcitonin reduce the need for empiric antibiotic treatment?

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Report by: David Herd, CED Fellow

Search checked by: Katie Cole Grimes, Specialty Registrar

Institution: Starship Children's Hospital (Auckland, NZ), Manchester Royal Infirmary (UK)


A short-cut review of the literature was carried out to establish whether the biological marker procalcitonin could safely rule out the diagnosis of meningococcal disease (MCD) in children. Using the below outlined search method and after the exclusion of the non-relevant papers, two were found to be relevant to the specific question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these are shown in table 3. The clinical bottom line is that the currently available …

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  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.