You are here

  • Home
  • Archive
  • Volume 35, Issue 3
  • Bet 1: A slower rate of initial N-acetylcysteine infusion in the treatment of acute paracetamol overdose to reduce adverse reactions

Article Text

Article menu
Download PDFPDF
Best evidence topic reports
Bet 1: A slower rate of initial N-acetylcysteine infusion in the treatment of acute paracetamol overdose to reduce adverse reactions
  1. C Reynard1,2,
  2. L Howard3
  1. 1 University of Manchester, Manchester, UK
  2. 2 Manchester University Foundation NHS Trust, Manchester, UK
  3. 3 Manchester Metropolitan University, Manchester, UK
  1. Correspondence to C Reynard; production.emj{at}bmj.com

https://doi.org/10.1136/emermed-2018-207515.2

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Clinical scenario

    While on a clinical shift in the emergency department you attend to a 24-year-old female who has taken a clinically significant paracetamol overdose and requires N-acetylcysteine (NAC), you are wondering if a reduction in infusion rate of NAC will reduce adverse side effects such as vomiting and nausea?

    Three-part question

    In an adult who has taken an acute clinically significant paracetamol overdose requiring treatment, does reducing the rate of the initial dose of NAC reduce adverse effects?

    Search strategy

    Ovid MEDLINE 1946 to present.

    Embase 1974 to 10 January …

    View Full Text

    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.