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While on a clinical shift in the emergency department you attend to a 24-year-old female who has taken a clinically significant paracetamol overdose and requires N-acetylcysteine (NAC), you are wondering if a reduction in infusion rate of NAC will reduce adverse side effects such as vomiting and nausea?
In an adult who has taken an acute clinically significant paracetamol overdose requiring treatment, does reducing the rate of the initial dose of NAC reduce adverse effects?
Ovid MEDLINE 1946 to present.
Embase 1974 to 10 January …
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.
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