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Issues and challenges for research in major trauma
  1. Sharon Ann Swain1,
  2. Graham Stiff2
  1. 1 National Guidelines Centre, Royal College of Physicians, London, UK
  2. 2 GP and Pre-hospital Emergency Physician, Newbury, UK
  1. Correspondence to Dr Sharon Ann Swain, National Guidelines Centre, Royal College of Physicians, London NW1 4LE, UK; sharon.swain{at}


The starting point for evidence-based guidelines is the systematic review and critical appraisal of the relevant literature. This review highlights the risk of bias identified while critically appraising the evidence to inform the National Institute of Health and Care Excellence guideline on the assessment and initial management of major trauma.

  • major trauma management
  • research
  • methods

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  • Contributors SAS wrote the sections on the methodological issues and GS provided clinical context and interpretation.

  • Funding This work was undertaken by the guideline development group of the Major trauma: Initial assessment and management which received funding from the National Institute for Health and Care Excellence (NICE).

  • Disclaimer The views expressed in this publication are those of the authors and not necessarily those of NICE.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.