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PP28 Tia prehospital referral feasibility trial (TIER): recruitment and intervention usage
  1. Nigel Rees1,
  2. Chelsey Hampton2,
  3. Jenna Bulger2,
  4. Khalid Ali3,
  5. Tom Quinn4,
  6. Gary Ford5,
  7. Ashley Akbari2,
  8. Matthew Ward6,
  9. Alison Porter2,
  10. Charlene Jones1,
  11. Helen Snooks2
  1. 1Welsh Ambulance Services NHS Trust, UK
  2. 2Swansea University, UK
  3. 3Brigthon and Sussex Medical School, UK
  4. 4Kingston University and St George’s University of London, UK
  5. 5Health Science Networks, Oxford University Hospitals, UK
  6. 6West Midlands Ambulance Service, UK


Background Early specialist assessment of Transient Ischaemic Attack (TIA) can reduce the risk of stroke and death. This study assessed feasibility of undertaking a multi-centre randomised trial to evaluate clinical and cost effectiveness of referral of patients attended by emergency ambulance paramedic with low-risk TIA directly to specialist TIA clinic for early review.

Methods We developed a protocol and referral pathway for paramedics to assess and refer patients directly to TIA clinic, including provision of aspirin. We randomly allocated volunteer paramedics to intervention or control group. Intervention paramedics were trained to deliver the intervention during the patient recruitment period. Control paramedics continued to deliver care as usual. Patients with TIA were identified from hospital records. We aimed to recruit 86 patients and pre-defined progression criteria related to feasibility of intervention delivery and trial methods.

Results Development and recruitment phases are complete, with outcome follow up ongoing. Eighty nine of 134 (66%) paramedics participated in TIER. Of 1377 patients attended by trial paramedics during the patient recruitment period, 53 (3.8%) were identified as eligible for trial inclusion. Three of 36 (8%) patients attended by intervention paramedics were referred to the TIA clinic. Of the others, only one appeared to be a missed referral; in one case there was no prehospital record of TIA; one was attended by a paramedic who was not TIER trained; one patient record was missing; all others were recorded with contraindications: FAST positive (n=13); ABCD2 score >3 (n=5); already taking warfarin (n=2); crescendo TIA (n=1) other clinical factors (n=8).

Conclusions Preliminary Results indicate challenges in recruitment and low referral rates. The low-risk 999 TIA population suitable for Emergency Department avoidance may be smaller than previously thought. Further analyses will focus on whether progression criteria for a definitive trial were met, and clinical outcomes from this feasibility trial.

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