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BET 1: Green or blue for you? Methoxyflurane (Penthrox) or nitrous oxide/oxygen 50% mixture (Entonox) for the management of acute pain in the ED
  1. Shah Mizanur Rahman1,
  2. Eimhear Quinn2
  1. 1 Thames Valley Deanery, Oxford, UK
  2. 2 Salford Royal NHS Foundation Trust, Salford, UK
  1. Correspondence to Shah Mizanur Rahman; production.emj{at}


A short-cut review of the literature was carried out to establish whether inhaled methoxyflurane (Penthrox) is comparable or superior with a standard inhalational analgesia for the management of acute pain. Only two papers were identified as suitable for inclusion using the reported search strategy. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of the best papers are tabulated. It is concluded that both methods of inhaled analgesia appear to be useful options for acute pain in the ED when compared with placebo. No evidence was found to suggest superiority of methoxypenflurane. International studies directly comparing the use of both drugs for in acute trauma are ongoing and will develop the evidence base.

  • emergency care systems

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  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.