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Regarding ‘moderate to severe hyperphosphataemia as an independent prognostic factor for 28-day mortality in adult patients with sepsis’
  1. Junteng Zhou1,
  2. Qi Zhang2,
  3. Xiaojing Liu1,3
  1. 1 Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China
  2. 2 Department of Endocrinology and Metabolism, Sichuan University West China Hospital, Chengdu, China
  3. 3 Laboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China
  1. Correspondence to Professor Xiaojing Liu, Laboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China; liuxq{at}scu.edu.cn

http://dx.doi.org/10.1136/emermed-2020-210598

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    Dear editor in chief,

    We have read an article written by Jang et al.1 The results of this paper and a previous study suggested that higher serum phosphate may be associated with higher mortality in individuals with sepsis.1 2 Several critical issues in the analysis should be considered in interpreting the results.

    The authors performed a multivariate analysis to adjust for confounders; however, blood urea nitrogen (BUN) and lactate were not included. Studies showed that blood lactate levels and BUN were positively associated with poor …

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    Footnotes

    • Handling editor Roland Merchant

    • Contributors JZ and QZ contributed equally to this manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; internally peer reviewed.