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I read with interest the article on validation of the Canadian Syncope Risk Score (CSRS) at six Italian hospitals. I applaud the efforts of Solbiati et al to validate the CSRS.1 However, the study has a few methodological flaws to trust the conclusions as reported.
First, the sample size. With just 345 patients of whom 43 patients with 30-day serious adverse event is a sample that is inadequate for a validation study. Unfortunately, the study has less than half of the recommended sample size: at least 100 patients with events and non-events, or 10 patients with events per predictor. …
Footnotes
Handling editor Richard Body
Contributors I am the sole author of the letter to the editor.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.