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Detection of rapid loss of intravascular volume due to haemorrhage or fluids can be a time-sensitive data point in critical situations. Clinical evaluation can be difficult and prior research has shown inaccuracies leading to increased morbidity and mortality.1 One way to measure this is through the assessment of capillary refill time (CRT), which has been shown to significantly vary between physicians.2 However, goal-directed fluid management often uses manual CRT measurements as a guiding metric. The goal of this study was to evaluate technology (PeriFRL by ProMedix Inc) to objectively measure CRT before and after healthy subjects donated blood. The hypothesis was that the CRT would become prolonged after donation.
All adult subjects over 17 years gave consent. All subjects over three separate 1-day periods who signed up to …
Footnotes
Handling editor Ed Benjamin Graham Barnard
Contributors DS is responsible for the overall content of this manuscript. He conceptualised the study, assisted with methodology, wrote the original draft and finalised editing/review. RS participated in data curation, formal analysis and was active in writing-editing and review. DW and PF participated in data curation and was active in writing-editing and review. JK conceptualised the study, assisted with methodology and was active in data analysis and writing-editing and review.
Funding This study was funded by ProMedix Inc: no award or grant number.
Competing interests DS has a financial interest in ProMedix Inc. DS is an employee of Oregon Health and Science University and this financial relationship is reviewed by two committees at Oregon Health and Science University and managed under a conflict of interest plan.
Provenance and peer review Not commissioned; externally peer reviewed.