TY - JOUR T1 - Pregnancy-associated plasma protein A: a novel cardiac marker with promise JF - Emergency Medicine Journal JO - Emerg Med J SP - 875 LP - 877 DO - 10.1136/emj.2006.042184 VL - 23 IS - 11 AU - Richard Body AU - Craig Ferguson Y1 - 2006/11/01 UR - http://emj.bmj.com/content/23/11/875.abstract N2 - Report by Richard Body, Clinical Research Fellow 
 Search checked by Craig Ferguson, Clinical Research Fellow 
 Manchester Royal Infirmary, Manchester, UK In [patients with chest pain of suspected cardiac origin] does [measurement of serum PAPP-A [pregnancy-associated plasma protein A] on admission] allow [exclusion of acute coronary syndromes]? A 45-year-old abusive, intoxicated recurrent attender complains of central chest pain of 2 h duration. His initial electrocardiogram is normal. Your gut feeling is that he does not have an acute coronary syndrome. You are reluctant to admit him for troponin estimation at 12 h, but wonder if you ought to risk discharge without further investigation. Having heard about PAPP-A, a promising cardiac marker, you wonder if the evidence is sufficient to allow it to … ER -