RT Journal Article SR Electronic T1 Limited analgesic efficacy of nitrous oxide for painful procedures in children JF Emergency Medicine Journal JO Emerg Med J FD BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine SP 717 OP 721 DO 10.1136/emj.2007.053751 VO 25 IS 11 A1 F E Babl A1 E Oakley A1 A Puspitadewi A1 L N Sharwood YR 2008 UL http://emj.bmj.com/content/25/11/717.abstract AB Study objective: Nitrous oxide (N2O) is an attractive agent for procedural analgesia and sedation of children in the emergency department (ED). Despite increasing use, efficacy data for painful procedures are limited. This study aimed to determine pain scores during ED procedural sedation with N2O in the ED setting.Methods: Prospective observational study of N2O use as a sole agent for procedural analgesia at a tertiary children’s hospital ED. Pain scores were obtained from patients and parents using visual analogue or faces scales, as appropriate. Parent and staff satisfaction with sedation and analgesia were assessed.Results: 124 children aged 1–17 years (mean 8.1) underwent procedural analgesia with N2O for 131 procedures. Most procedures were orthopaedic (44%) or laceration repair (30%). In 51% of patients (95% CI 42% to 60 to 23%) pain scores remained unchanged and in 34% (95% CI 26% to 43%) pain scores increased. Overall, 34% (95% CI 26% to 43%) patients had intraprocedural scores of 50 mm or greater and 21% (95% CI 14% to 29%) had pain scores of 70 mm or greater. Some procedures such as fracture reduction had a larger proportion of patients with high pain scores or 50 mm or greater (45%) and 70 mm or greater (29%). Staff rated both sedation and analgesia as “adequate” in 92%. Parents contacted in follow-up were satisfied or very satisfied with procedures in 96% and sedations in 93%.Conclusion: Data indicate that parents and staff are generally satisfied with N2O for procedural use in the ED. The efficacy of N2O as a sole agent in very painful procedures is limited.