PT  - JOURNAL ARTICLE
AU  - H K R Thanacoody
TI  - Chronic valproic acid intoxication: reversal by naloxone
AID  - 10.1136/emj.2007.049791
DP  - 2007 Sep 01
TA  - Emergency Medicine Journal
PG  - 677--678
VI  - 24
IP  - 9
4099  - http://emj.bmj.com/content/24/9/677.short
4100  - http://emj.bmj.com/content/24/9/677.full
SO  - Emerg Med J2007 Sep 01; 24
AB  - A 76-year-old woman being treated with sodium valproate for bipolar depression presented with a 4 day history of acute confusion and tremulousness. She had apnoeic episodes, reduced conscious level and generalised myoclonic movements. Her plasma valproate concentration was 848 µmol/l (normal 300–600 µmol/l). Administration of naloxone 0.8 mg led to rapid clinical improvement. Naloxone may be useful in reversing the features of chronic valproate toxicity.