TY - JOUR T1 - Chronic valproic acid intoxication: reversal by naloxone JF - Emergency Medicine Journal JO - Emerg Med J SP - 677 LP - 678 DO - 10.1136/emj.2007.049791 VL - 24 IS - 9 AU - H K R Thanacoody Y1 - 2007/09/01 UR - http://emj.bmj.com/content/24/9/677.abstract N2 - A 76-year-old woman being treated with sodium valproate for bipolar depression presented with a 4 day history of acute confusion and tremulousness. She had apnoeic episodes, reduced conscious level and generalised myoclonic movements. Her plasma valproate concentration was 848 µmol/l (normal 300–600 µmol/l). Administration of naloxone 0.8 mg led to rapid clinical improvement. Naloxone may be useful in reversing the features of chronic valproate toxicity. ER -