RT Journal Article
SR Electronic
T1 Serum adenosine deaminase levels in diagnosis of acute appendicitis
JF Emergency Medicine Journal
JO Emerg Med J
FD BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine
SP 583
OP 585
DO 10.1136/emj.2007.054452
VO 25
IS 9
A1 Z A Öztürk
A1 S Köklü
A1 M F Erol
A1 F M Yılmaz
A1 Ö Başar
A1 O Yüksel
A1 G Yılmaz
A1 B Kısacık
A1 İ Yüksel
YR 2008
UL http://emj.bmj.com/content/25/9/583.abstract
AB Background: Adenosine deaminase (ADA) is found in most tissues including lymphoid cells and lymph nodes. It is a marker of T lymphocyte activation. The role of type 1 and type 2 T helper cells in appendicitis has been investigated experimentally. Serum ADA levels in acute appendicitis have not previously been studied.Aim: To assess the serum levels of ADA in patients with acute appendicitis.Methods: Serum levels of ADA were investigated in 30 cases with acute appendicitis (mean age 26 years; male/female 17/13) and 21 healthy controls (mean age 40 years; male/female 11/10). Levels of ADA were compared in patients with acute appendicitis and healthy controls. Correlation analysis between ADA and other inflammatory markers (C-reactive protein (CRP), high-sensitivity CRP, erythrocyte sedimentation rate and white blood cell count) was also performed.Results: Mean (SD) serum ADA levels were significantly higher in those with acute appendicitis than in the control group (13.41 (3.56) U/l vs 9.39 (1.22) U/l; p<0.001). There was no correlation between ADA and the other inflammatory markers investigated.Conclusions: Although serum levels of ADA do not correlate with other known inflammatory markers, its serum level is increased in acute appendicitis and it has a higher positive predictive value.