PT  - JOURNAL ARTICLE
AU  - Ayça Açıkalın
AU  - Yüksel Gökel
TI  - Serum IL-6, TNFα levels in snakebite cases occurring in Southern Turkey
AID  - 10.1136/emj.2009.078428
DP  - 2011 Mar 01
TA  - Emergency Medicine Journal
PG  - 208--211
VI  - 28
IP  - 3
4099  - http://emj.bmj.com/content/28/3/208.short
4100  - http://emj.bmj.com/content/28/3/208.full
SO  - Emerg Med J2011 Mar 01; 28
AB  - Objective The snake species Vipera ammodytes meridionalis and Vipera lebetina obtuse are often seen in Southern Turkey and have venom that causes serious systemic and tissue damage. The aim of our study is to assess the relationship between tumour necrosis factor α (TNFα) and interleukin 6 (IL-6) serum levels, and clinical and laboratory findings in the snakebite patients.Methods 26 patients who had received snakebites were included in a prospective study. Patients were grouped according to their clinical presentations in order to plan treatment.Results TNFα serum levels of most patients who went to the emergency room to receive treatment for snakebite were high. This increase was most likely to be related to the clinical severity of the snakebite and the length of time between the snakebite and their arrival at the hospital. In contrast to TNFα, there was no relationship between serum IL-6 levels and clinical and laboratory parameters.Conclusions Snakebites from Vipera ammodytes meridionalis and Vipera lebetina obtuse lead to increased levels of serum TNFα. However, serum TNFα and IL-6 levels depend on various factors such as the kind of snake, the area the venom was injected into, the amount of venom and the body size of the patients.