PT  - JOURNAL ARTICLE
AU  - Dedic, Admir
AU  - ten Kate, Gert-Jan
AU  - Rood, Pleunie P M
AU  - Galema, Tjebbe W
AU  - Ouhlous, Mohamed
AU  - Moelker, Adriaan
AU  - de Feyter, Pim J
AU  - de Rijke, Yolanda B
AU  - Nieman, Koen
TI  - Copeptin in acute chest pain: identification of acute coronary syndrome and obstructive coronary artery disease on coronary CT angiography
AID  - 10.1136/emermed-2012-201596
DP  - 2013 Nov 01
TA  - Emergency Medicine Journal
PG  - 910--913
VI  - 30
IP  - 11
4099  - http://emj.bmj.com/content/30/11/910.short
4100  - http://emj.bmj.com/content/30/11/910.full
SO  - Emerg Med J2013 Nov 01; 30
AB  - Objective To determine the diagnostic accuracy of copeptin in patients with suspected acute coronary syndrome (ACS) and its correlation with obstructive coronary artery disease (CAD) on coronary CT angiography (CTA). Methods Copeptin was measured at arrival in 65 consecutive patients (56±10 years, 45 men) suspected of ACS and no indication for immediate invasive angiography. All patients underwent coronary CTA without disclosure of the results to the treating physician, and outcomes were classified as obstructive CAD (>50% stenosis) or no obstructive CAD (≤50%) in one or more vessel. Results The final diagnosis of ACS was established in 10 (15%) patients, 6 myocardial infarctions and 4 unstable angina pectoris. Coronary CTA detected obstructive CAD in all patients with ACS and in 10 (15%) patients with no ACS. Copeptin concentrations were higher in patients with ACS (median 7.42 pmol/l (IQR 3.71–18.72)) vs patients with no ACS (3.40 pmol/l (1.13–6.27), p=0.02). Copeptin was not higher in patients with obstructive CAD on coronary CTA (4.87 pmol/l (2.90–8.51) vs 3.60 pmol/l (1.21–6.23), p=0.20) compared with patients with no obstructive CAD. Conclusions Copeptin seems to be elevated in patients with ACS while there is no strong correlation with obstructive coronary disease on CTA.